Document Detail

β-Carboline alkaloids from the leaves of Trigonostemon lii Y.T. Chang.
MedLine Citation:
PMID:  22342628     Owner:  NLM     Status:  Publisher    
A phytochemical work on the alkaloid constituents from Trigonostemon lii Y.T. Chang was conducted to give six new β-carboline alkaloids, trigonostemines A-F (1-6) and eight known β-carboline alkaloids (7-14). Their structures were elucidated by extensive spectroscopic techniques including 2D NMR experiments and mass spectrometry. All of the compounds were evaluated for their cytotoxic activities against the HL-60, SMMC-7721, A-549, MCF-7, and SW480 human cancer cell lines. Trigonostemines A and B (1 and 2) exhibited stronger inhibitory activities than the positive control (cisplatin) in some cell lines.
Shi-Fei Li; Yu Zhang; Yan Li; Xin-Rao Li; Ling-Mei Kong; Cheng-Jian Tan; Shun-Lin Li; Ying-Tong Di; Hong-Ping He; Xiao-Jiang Hao
Related Documents :
10496218 - A selection system for functional internal ribosome entry site (ires) elements: analysi...
17135188 - Cellular delivery of small interfering rna by a non-covalently attached cell-penetratin...
9826678 - Inhibition of tumorigenicity of the teratoma pc cell line by transfection with antisens...
10925268 - In vitro and in vivo transfection of p21 gene enhances cyclosporin a-mediated inhibitio...
3190658 - Ultrastructure of electrophysiologically identified human sinoatrial nodes.
15706508 - Intercellular communications induced by random fluctuations.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-3
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  -     ISSN:  1464-3405     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ltd.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China; Graduate University of Chinese Academy of Sciences, Beijing 100039, People's Republic of China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-...
Next Document:  Synthesis and structure-activity relationship of 5-substituent-2(1H)-pyridone derivatives as anti-fi...