Document Detail

Carboline Alkaloids from Psammosilene tunicoides and Their Cytotoxic Activities.
MedLine Citation:
PMID:  22411729     Owner:  NLM     Status:  Publisher    
Five new carboline alkaloids, tunicoidines A-E ( 1- 5), and two known carboline alkaloids, 1-acetyl- β-carboline-3-carboxylic acid ( 6) and 1-acetyl-3-carbomethoxyl- β-carboline ( 7), were isolated for the first time from the root of PSAMMOSILENE TUNICOIDES. The structures of the new carboline alkaloids were established on the basis of 1D- and 2D-NMR, and HR-MS spectroscopic analyses. The seven compounds were evaluated for cytotoxicity against A549, HCT116, ZR-75-30, and HL-60 cell lines. However, only compound 7 had potent cytotoxic activity against the HCT116 cell line with an IC (50) value of 9.67 µg/mL, while the others showed no cytotoxic activities against the four tested cell lines.
Junmian Tian; Yunheng Shen; Huiliang Li; Runhui Liu; Lei Shan; Jinming Gao; Weidong Zhang
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Publication Detail:
Type:  LETTER     Date:  2012-3-12
Journal Detail:
Title:  Planta medica     Volume:  -     ISSN:  1439-0221     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai, P. R. China.
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