Document Detail

Carbohydrate storage in man: speculations and some quantitative considerations.
MedLine Citation:
PMID:  723637     Owner:  NLM     Status:  MEDLINE    
Recent information indicates that the capacity of man to store carbohydrate energy by transformation into fatty acids synthetized de novo is very limited in adipose tissue as well as in liver and intestine. This seems to be in contrast to other species such as the rat where de novo fatty acid synthesis can be induced to a high capacity of glucose removal. This leaves man with a limited capacity to store excess carbohydrate. The remaining possibilities are both the main glycogen stores in liver and in muscle. The latter is by far the largest. The capacity of muscle to assimilate glucose is dependent on its glycogen content that in turn is dependent on previous glycogen depletion to supply energy for muscle contraction. Man might, thus, be uniquely limited in the capacity to dispose of extra carbohydrate in the sedentary state. This might speculatively be thought to be an explanation for a carbohydrate excess syndrome in the sedentary state that may well increase the risk for obesity, hyperinsulinemia, and diabetes mellitus. The logical treatment for such a syndrome then is either a decreased intake of energy as carbohydrate or an increased disposal of carbohydrate energy by exercise. Exercise has, indeed, been shown to have such effects both after physical training programs and, perhaps more pertinent to the question, during a few days after a single exercise bout that has consumed a large amount of muscle glycogen.
P Björntorp; L Sjöström
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  27     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  1978 Dec 
Date Detail:
Created Date:  1979-02-12     Completed Date:  1979-02-12     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1853-65     Citation Subset:  IM    
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MeSH Terms
Adipose Tissue / metabolism*
Carbohydrate Metabolism*
Dietary Carbohydrates
Energy Metabolism
Fatty Acids / biosynthesis
Glucose / metabolism
Glycerol / biosynthesis
Intestinal Absorption
Lipids / biosynthesis
Triglycerides / biosynthesis
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Fatty Acids; 0/Lipids; 0/Triglycerides; 50-99-7/Glucose; 56-81-5/Glycerol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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