Document Detail

Carbohydrate and satiety.
MedLine Citation:
PMID:  12078914     Owner:  NLM     Status:  MEDLINE    
This review focuses on what is known about the effects of carbohydrate on food intake, the potential mechanisms mediating these effects, and the impact of different monosaccharides in humans. The inhibition of subsequent food intake associated with ingestion of carbohydrate appears to result primarily from gastrointestinal signals, including those generated by orosensory stimulation, gastric distension, and perhaps most importantly the interaction of nutrients with receptors in the small intestine. The latter is associated with the release of putative satiety hormones, including glucagon-like peptide-1 and amylin, and slowing of both gastric emptying and small intestinal transit (thereby prolonging gastric distension and increasing the time available for nutrient absorption). The effects of carbohydrate on food intake are dependent on the route of administration (i.e., oral, intragastric, or intraduodenal). Changes in blood glucose and insulin concentrations per se probably do not play a major role in the induction of satiety. Studies relating to the comparative effects of different monosaccharides/carbohydrates have yielded inconclusive results, probably in part owing to substantial differences in methodological approaches.
Christine Feinle; Deirdre O'Donovan; Michael Horowitz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Nutrition reviews     Volume:  60     ISSN:  0029-6643     ISO Abbreviation:  Nutr. Rev.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-24     Completed Date:  2002-08-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0376405     Medline TA:  Nutr Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  155-69     Citation Subset:  IM    
Department of Medicine, Royal Adelaide Hospital, SA, Australia.
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MeSH Terms
Dietary Carbohydrates / administration & dosage*,  metabolism*
Digestive System Physiological Phenomena*
Eating / physiology*
Monosaccharides / administration & dosage*,  metabolism*
Papio / physiology
Satiety Response / physiology*
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Monosaccharides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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