| Carbohydrate restriction favorably alters lipoprotein metabolism in Emirati subjects classified with the metabolic syndrome. | |
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MedLine Citation:
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PMID: 19748249 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND AND AIMS: Carbohydrate restriction (CR) has been shown to improve dyslipidemias associated with metabolic syndrome (MetS). We evaluated the effects of CR on lipoprotein subfractions and apolipoproteins in Emirati adults classified with the MetS. METHODS AND RESULTS: 39 subjects (15 men/24 women) were randomly allocated to a CR diet [20-25% energy from carbohydrate (CHO)] for 12 wk (CRD group) or a combination treatment consisting of CRD for 6 wk followed by the American Heart Association diet (50-55% CHO, AHA group) for an additional 6 wk. All subjects reduced body weight, LDL cholesterol and triglycerides (P<0.01). At baseline all subjects had low concentrations of medium VLDL and total HDL particles associated with the very low plasma triglycerides and HDL cholesterol in this population. After 12 wk, the large VLDL subfraction was decreased over time for subjects in the CRD group (P<0.01) while these changes were not observed in those subjects who changed to the AHA diet. The number of medium and small LDL particles decreased for all subjects rendering a less atherogenic lipoprotein profile. In agreement with these results, a significant decrease in apolipoprotein (apo) B was observed (P<0.01). The medium HDL subfraction and apo A-II, which can be considered pro-atherogenic, were also decreased over time in the CRD group only. CONCLUSIONS: These results suggest that weight loss favorably affects lipoprotein metabolism and that the CRD had a better effect on atherogenic VLDL and HDL than the low fat diet recommended by AHA. |
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Authors:
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T Al-Sarraj; H Saadi; J S Volek; M L Fernandez |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-09-12 |
Journal Detail:
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Title: Nutrition, metabolism, and cardiovascular diseases : NMCD Volume: 20 ISSN: 1590-3729 ISO Abbreviation: Nutr Metab Cardiovasc Dis Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9111474 Medline TA: Nutr Metab Cardiovasc Dis Country: Germany |
Other Details:
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Languages: eng Pagination: 720-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2009 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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