Document Detail


Carbohydrate quantity and quality and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition-Netherlands (EPIC-NL) study.
MedLine Citation:
PMID:  20685945     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Carbohydrate quantity and quality may play an important role in the development of type 2 diabetes.
OBJECTIVE: We investigated the associations of dietary glycemic load (GL), glycemic index (GI), carbohydrate, and fiber intake with the incidence of type 2 diabetes.
DESIGN: A prospective cohort study was conducted in 37,846 participants of the EPIC-NL (European Prospective Investigation into Cancer and Nutrition-Netherlands) study, aged 21-70 y at baseline and free of diabetes. Dietary intake was assessed with the use of a validated food-frequency questionnaire. Incident diabetes cases were mainly self-reported and verified against general practitioner records.
RESULTS: During a mean follow-up of 10 y, 915 incident diabetes cases were documented. Dietary GL was associated with an increased diabetes risk after adjustment for age, sex, established diabetes risk factors, and dietary factors [hazard ratio (HR) per SD increase: 1.27; 95% CI: 1.11, 1.44; P < 0.001] [corrected]. GI tended to increase diabetes risk (HR: 1.08; 95% CI: 1.00, 1.17; P = 0.05). Dietary fiber was inversely associated with diabetes risk (HR: 0.92; 95% CI: 0.85, 0.99; P < 0.05), whereas carbohydrate intake was associated with increased diabetes risk (HR: 1.15; 95% CI: 1.01, 1.32; P < 0.05). Of the carbohydrate subtypes, only starch was related to increased diabetes risk [HR: 1.25 (1.07, 1.46), P < 0.05]. All associations became slightly stronger after exclusion of energy misreporters.
CONCLUSIONS: Diets high in GL, GI, and starch and low in fiber were associated with an increased diabetes risk. Both carbohydrate quantity and quality seem to be important factors in diabetes prevention. Energy misreporting contributed to a slight attenuation of associations.
Authors:
Ivonne Sluijs; Yvonne T van der Schouw; Daphne L van der A; Annemieke M Spijkerman; Frank B Hu; Diederick E Grobbee; Joline W Beulens
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-04
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  92     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-21     Completed Date:  2010-10-27     Revised Date:  2011-03-29    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  905-11     Citation Subset:  AIM; IM    
Affiliation:
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands. i.sluijs-2@umcutrecht.nl
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Basal Metabolism
Cohort Studies
Diabetes Mellitus, Type 2 / epidemiology*
Dietary Carbohydrates / adverse effects*,  standards
Energy Intake
Europe / epidemiology
Female
Food Habits
Glycemic Index
Humans
Male
Middle Aged
Netherlands / epidemiology
Proportional Hazards Models
Prospective Studies
Questionnaires
Risk Factors
Starch
Sucrose
Young Adult
Chemical
Reg. No./Substance:
0/Dietary Carbohydrates; 57-50-1/Sucrose; 9005-25-8/Starch
Comments/Corrections
Comment In:
Am J Clin Nutr. 2010 Oct;92(4):675-7   [PMID:  20810974 ]
Erratum In:
Am J Clin Nutr. 2011 Mar;93(3):676

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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