Document Detail

Carbohydrate moieties as vaccine candidates.
MedLine Citation:
PMID:  16080094     Owner:  NLM     Status:  MEDLINE    
Carbohydrate epitopes or glycotopes are structurally diverse, occur in a variety of chemical contexts, and are present on the surfaces of cells in the body and on the surfaces of pathogens. These various structures and modes of presentation affect how they are perceived and processed by the body and dictate the outcome of the immune response directed against them. This review focuses on mechanisms of carbohydrate immunity, with an emphasis on carbohydrate vaccines that have been or are being developed for protection against encapsulated bacterial pathogens. We discuss the cellular basis of carbohydrate immunity, newly identified glycotope processing pathways and recognition capabilities, and the synthetic and microarray technologies that are being developed that will permit new experimental approaches to carbohydrate vaccine development and the exploration of the interaction of the immune system with self and nonself glycans.
Alexander H Lucas; Michael A Apicella; Christopher E Taylor
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Publication Detail:
Type:  Journal Article; Review     Date:  2005-07-25
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  41     ISSN:  1537-6591     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-08-04     Completed Date:  2006-08-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  705-12     Citation Subset:  IM    
Children's Hospital Oakland Research Institute, Oakland, California, USA.
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MeSH Terms
Antibodies, Bacterial / immunology
Bacterial Infections / prevention & control
Bacterial Vaccines / immunology*
Carbohydrates / immunology*
Epitopes / immunology
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Bacterial Vaccines; 0/Carbohydrates; 0/Epitopes

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