Document Detail

Carbohydrate malabsorption in black and Hispanic dialysis patients.
MedLine Citation:
PMID:  3740026     Owner:  NLM     Status:  MEDLINE    
Patients on chronic hemodialysis have decreased food intake and decreased fat stores. Malabsorption of carbohydrates such as lactose, sorbitol, or fructose cause functional bowel symptoms. The aim of this study was to assess the role of carbohydrate malabsorption in the nutritional abnormalities of chronic hemodialysis (CHD). Eleven patients on dialysis (six Hispanic, five black Americans) were studied, compared to 11 healthy volunteers age-, race-, and sex-matched. Lactulose 10 g (transit time), lactose 12.5 g, sorbitol 5 g, and fructose 37.5 g were tested fasting. Breath [H2] was measured 4 h postprandially by gas chromatograph analysis. Positive test was defined as 20 ppm [H2] above baseline. Weight, height, and triceps skinfold were measured. One hundred percent of CHD patients were below the 50th percentile for triceps skinfold measurement and 55% were below the 10th percentile. No biochemical abnormalities were noted. Breath [H2] tests: lactulose: all patients in both groups responded with positive tests. No difference in transit time was noted. Lactose: 73% of CHD had positive test compared to 36% control. Sorbitol: 73% of CHD had positive test compared to 27% control (p less than 0.05). Fructose: 27% CHD compared to 0% control. This study confirmed that CHD patients have decreased fat stores. It demonstrates for the first time that CHD patients have increased incidence of malabsorption of sorbitol. This carbohydrate malabsorption may contribute to the nutritional abnormalities of CHD.
M J Coyne; H Rodriguez
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  81     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-09-17     Completed Date:  1986-09-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  662-5     Citation Subset:  IM    
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MeSH Terms
African Americans*
Breath Tests
Dietary Carbohydrates / metabolism*
Fructose / metabolism
Hispanic Americans*
Hydrogen / analysis
Intestinal Absorption
Lactose / metabolism
Lactose Intolerance / epidemiology
Lactulose / metabolism
Malabsorption Syndromes / epidemiology*
Middle Aged
Renal Dialysis* / adverse effects
Skinfold Thickness
Sorbitol / metabolism
Reg. No./Substance:
0/Dietary Carbohydrates; 1333-74-0/Hydrogen; 30237-26-4/Fructose; 4618-18-2/Lactulose; 50-70-4/Sorbitol; 63-42-3/Lactose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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