| Carbohydrate and lipid metabolism in cockroach (Periplaneta americana) fat body are both activated by low and similar concentrations of Peram-AKH II. | |
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MedLine Citation:
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PMID: 18215441 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Injection of 0.1 pmol of the octapeptide Peram-AKH II (pGlu-Leu-Thr-Phe-Thr-Pro-Asn-TrpNH(2)) elicits a significant hypertrehalosemic response in the American cockroach, Periplaneta americana; a maximal effect is obtained with 1pmol. The latter amount also lowers the level of neutral lipid (NL) and phospholipid (PL) in the hemolymph. The evidence supports the idea that Peram-AKH II promotes the liberation of fatty acids from hemolymph phospholipid, and indirectly diacylglycerol in the same compartment. The fatty acids are then transported into the fat body where they are converted into triacylglycerol for storge. Because lipolysis and trehalose synthesis are initiated by a common concentration of Peram-AKH II it is reasonable to suggest that the physiological function of Peram-AKH II involves the participation of both metabolic pathways. |
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Authors:
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Julia Michitsch; John E Steele |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-12-05 |
Journal Detail:
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Title: Peptides Volume: 29 ISSN: 0196-9781 ISO Abbreviation: Peptides Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-12 Completed Date: 2008-05-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8008690 Medline TA: Peptides Country: United States |
Other Details:
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Languages: eng Pagination: 226-34 Citation Subset: IM |
Affiliation:
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Department of Biology, The University of Western Ontario, London, ON, Canada N6G 2K7. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport / drug effects Carbohydrate Metabolism / drug effects* Fat Body / drug effects, metabolism* Fatty Acids, Nonesterified / metabolism Hemolymph / drug effects, metabolism Insect Hormones / pharmacology Lipid Metabolism / drug effects* Lipids / blood Male Neuropeptides / pharmacology* Periplaneta / metabolism* Phospholipids / blood, metabolism Trehalose / blood, metabolism Triglycerides / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Nonesterified; 0/Insect Hormones; 0/Lipids; 0/Neuropeptides; 0/Phospholipids; 0/Triglycerides; 93240-39-2/glutamyl-leucyl-threonyl-phenylalanyl-threonyl-prolyl-asparaginyl-tryptophanamide; 99-20-7/Trehalose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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