Document Detail

Carbohydrate and lipid abnormalities in infants of diabetic mothers.
MedLine Citation:
PMID:  3990151     Owner:  NLM     Status:  MEDLINE    
Abnormalities of carbohydrate and lipid metabolism in infants of diabetic mothers are accounted for by maternal hyperglycemia shortly before and during delivery, and are caused by excessive fetal insulin secretion at birth. Thus, hypoglycemia and suppressed lipolysis (low serum free fatty acid and blood ketone body concentrations) in the newborn infant are correlated with cord serum C-peptide and free insulin levels at birth. Hypoglycemia is usually self-correcting, and treatment is required only in symptomatic or prolonged (over 6 hr) cases' Postheparin plasma lipoprotein lipase activity is twice as high in infants of diabetic mothers as in infants of normal mothers; this enzyme is inducible by insulin. For optimal homeostasis of the fetus and newborn infant, careful control of maternal blood glucose is necessary, not only during pregnancy but also during delivery.
K O Raivio
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Klinische Pädiatrie     Volume:  197     ISSN:  0300-8630     ISO Abbreviation:  Klin Padiatr     Publication Date:    1985 Mar-Apr
Date Detail:
Created Date:  1985-06-20     Completed Date:  1985-06-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0326144     Medline TA:  Klin Padiatr     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  159-60     Citation Subset:  IM    
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MeSH Terms
Blood Glucose / metabolism*
Infant, Newborn
Lipids / blood*
Lipoprotein Lipase / metabolism
Maternal-Fetal Exchange*
Pregnancy in Diabetics / enzymology*
Reg. No./Substance:
0/Blood Glucose; 0/Lipids; EC Lipase

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