| Carbohydrate intake, serum lipids and apolipoprotein E phenotype show association in children. | |
| | |
MedLine Citation:
|
PMID: 19563454 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIM: To study the association between carbohydrate intake and serum lipids in children, and influence of apolipoprotein E phenotype (apoE) on the association. SUBJECTS/METHODS: A total of 644 children from a prospective, randomized atherosclerosis prevention trial (STRIP) participated in this longitudinal study at age 5 (n = 644), 7 (n = 585) and 9 (n = 550) years. ApoE phenotype, fasting triglyceride, total, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol concentrations and 4-day food records were analysed. RESULTS: An increase in the total carbohydrate intake by 1 E% (percentage of total daily energy intake) associated with a decrease in HDL cholesterol by 0.006 mmol/L (p < 0.001) when adjusted for saturated, monounsaturated and polyunsaturated fatty acid, age, gender, body mass index and STRIP study group. The inverse association between total carbohydrate intake and HDL cholesterol was evident in children with apoE3 (p < 0.001) or apoE4 (p < 0.001), but not in those with apoE2 (p = 0.78). An increase in total carbohydrate intake by 1 E% increased triglycerides by 0.02 mmol/L (p < 0.001) independently of apoE phenotype, while 1 E% increase in sucrose intake increased triglycerides by 0.01 mmol/L (p < 0.001). CONCLUSION: Carbohydrate intake has a relatively small effect on serum lipids in children. Children with the apoE3 or E4 but not with E2 phenotype show reduction in HDL cholesterol with increasing carbohydrate intake indicating that genetic and environmental factors interact with children's lipoprotein metabolism. |
| | |
Authors:
|
Soile Ruottinen; Tapani Rönnemaa; Harri Niinikoski; Hanna Lagström; Maiju Saarinen; Katja Pahkala; Tuuli Kaitosaari; Jorma Viikari; Olli Simell |
Related Documents
:
|
2589304 - Increase in body fatness as a major determinant of changes in serum total cholesterol a... 527884 - Oxalate loading test: a screening test for steatorrhoea. 12948274 - No effect of garlic extract supplement on serum lipid levels in hypercholesterolemic su... 1599344 - Saturated fats, cholesterol, and dietary compliance. 3928844 - The influence of protein and/or energy deficiency on the growth of long bone in rats. 21794014 - Effect of supplementation of soy sauce oil and ca salts of fatty acids on rumen ferment... |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2009-06-26 |
Journal Detail:
|
Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 98 ISSN: 1651-2227 ISO Abbreviation: Acta Paediatr. Publication Date: 2009 Oct |
Date Detail:
|
Created Date: 2009-10-21 Completed Date: 2009-12-03 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: Norway |
Other Details:
|
Languages: eng Pagination: 1667-73 Citation Subset: IM |
Affiliation:
|
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. soile.ruottinen@utu.fi |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Analysis of Variance Apolipoproteins E / genetics* Child Child Nutritional Physiological Phenomena* Child, Preschool Cholesterol, HDL / blood Cholesterol, LDL / blood Dietary Carbohydrates / administration & dosage* Female Humans Lipids / blood* Male Multivariate Analysis Phenotype Prospective Studies Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
|
0/Apolipoproteins E; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Dietary Carbohydrates; 0/Lipids; 0/Triglycerides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A review of the effect of the psychosocial working environment on physiological changes in blood and...
Next Document: Baby walkers: a perspective from Turkey.