Document Detail

Carbohydrate ingestion improves oxygen delivery in acute hypoxia.
MedLine Citation:
PMID:  18331221     Owner:  NLM     Status:  MEDLINE    
It is generally accepted that an increase in blood CO(2) increases ventilation. We also know that during carbohydrate metabolism a larger amount of CO(2) is produced than during metabolism of lipids or proteins. The aim of the present study was therefore to assess whether carbohydrate ingestion can increase CO(2) production enough to stimulate ventilation, which could in turn increase arterial oxygenation and alleviate the symptoms of hypoxia in a hypoxic environment. Fourteen subjects participated in two trials, which consisted of two normoxic and an acute hypoxic period (F(i(O(2))) = 12.86%). Following the first control normoxic period, the subjects ingested either a 10% water solution of sucrose (CHO; 4 kcal/kg body mass) or an equal volume of water (control). Hemoglobin saturation, heart rate, and ventilation parameters were monitored throughout the experiment. In contrast to the control trial, CO(2) production (V(CO(2)); L), ventilation (V; L/min), and heart rate were all significantly (p < 0.001) increased in the CHO trial during the second normoxic exposure; these parameters were also significantly elevated during the hypoxic exposure, as compared to the control trial. Carbohydrate ingestion 40 min prior to acute hypoxic exposure significantly (p < 0.001) improved hemoglobin saturation by 4%. The results suggest that ingestion of carbohydrates can improve arterial oxygenation during acute hypoxic exposure.
Petra Golja; Polona Flander; Matjaz Klemenc; Jerica Maver; Tanja Princi
Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  High altitude medicine & biology     Volume:  9     ISSN:  1527-0297     ISO Abbreviation:  High Alt. Med. Biol.     Publication Date:  2008  
Date Detail:
Created Date:  2008-03-11     Completed Date:  2008-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901183     Medline TA:  High Alt Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  53-62     Citation Subset:  IM; S    
University of Nova Gorica, Centre for Environmental and Sports Physiology, Nova Gorica, Slovenia.
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MeSH Terms
Altitude Sickness / blood*,  prevention & control
Anoxia / blood*,  prevention & control
Blood Glucose / metabolism
Carbohydrate Metabolism*
Heart Rate / drug effects
Oxygen / blood*
Oxygen Consumption / drug effects*
Pulmonary Ventilation / drug effects
Reference Values
Sucrose / administration & dosage*
Reg. No./Substance:
0/Blood Glucose; 57-50-1/Sucrose; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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