| Carbohydrate-enriched diet impairs cardiac performance by decreasing the utilization of fatty acid and glucose. | |
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MedLine Citation:
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PMID: 21282201 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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AIMS: We hypothesized that a high-carbohydrate diet affects the cardiac performance by interfering in the metabolic steps involved in energy transfer in this organ. To verify this, we investigated the myocardial utilization of different substrates and contractile function in rats fed a high-carbohydrate diet, under normal flow and ischemia. METHODS: and RESULTS: Male Wistar rats were fed over 9 days with standard (39.5% carbohydrate, 8% fiber) or high-carbohydrate diet (58% carbohydrate) and, afterwards, their cardiac function was examined using isolated heart preparations. The high-carbohydrate diet decreased the activity of the lipoprotein lipase, utilization of fatty acids, expression of the gene of peroxisome proliferator-activated receptor α and its target enzymes. In addition, decreased GLUT4 mass, glucose uptake, glycogen content and glycolytic intermediates were also observed. High-carbohydrate hearts displayed weaker activation of the glycolytic pathway during ischemia, according to minor production of lactate, in relation to control hearts. The functional impairment caused by high-carbohydrate diet shown by the decrease in the ventricular systolic strength, +dT/dt and -dT/dt was, at least in part, due to the low availability of adenosine triphosphate (ATP). CONCLUSION: Our data suggest that a high-carbohydrate diet can damage myocardial contractile function by decreasing the cardiac utilization of glucose and fatty acids and, consequently, the ATP pool. |
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Authors:
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Laura C J Pôrto; Sílvia S Q Savergnini; Carlos H de Castro; Erica G Mario; Adaliene V M Ferreira; Sérgio H S Santos; Sílvia P Andrade; Robson A S Santos; Alvair P de Almeida; Leida M Botion |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Therapeutic advances in cardiovascular disease Volume: 5 ISSN: 1753-9455 ISO Abbreviation: Ther Adv Cardiovasc Dis Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101316343 Medline TA: Ther Adv Cardiovasc Dis Country: England |
Other Details:
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Languages: eng Pagination: 11-22 Citation Subset: IM |
Affiliation:
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Department of Food Science, Federal University of Lavras, Lavras, MG, Brazil 37200-000 and Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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