Document Detail

Carbohydrate deposits on the surfaces of worn extended-wear soft contact lenses.
MedLine Citation:
PMID:  3475046     Owner:  NLM     Status:  MEDLINE    
Three different commercial extended-wear soft contact lenses worn continuously by patients for at least 28 days were stained with fluorescein isothiocyanate-labeled lectins. These lectins detected the presence of alpha-linked or beta-linked D-mannose, D-glucose, D-galactose, L-fucose, N-acetyl-D-glucosamine, N-acetyl-D-galactosamine, and N-acetyl neuraminic acid (sialic acid) on the surfaces of the contact lenses. These saccharides are bound to other sugars that likely account for an integral part of glycoprotein and/or glycolipid deposits on lens surfaces. These tear deposits may contribute to the chemical spoilage of the lens and, furthermore, may serve as specific receptors for pathogenic microorganisms commonly implicated in extended-wear soft contact lens-associated infectious keratitis.
S A Klotz; R P Misra; S I Butrus
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  105     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  1987 Jul 
Date Detail:
Created Date:  1987-08-03     Completed Date:  1987-08-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  974-7     Citation Subset:  AIM; IM    
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MeSH Terms
Contact Lenses, Extended-Wear*
Contact Lenses, Hydrophilic*
Hexosamines / analysis*
Monosaccharides / analysis*
N-Acetylneuraminic Acid
Sialic Acids / analysis*
Reg. No./Substance:
0/Hexosamines; 0/Monosaccharides; 0/Sialic Acids; 131-48-6/N-Acetylneuraminic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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