Document Detail

Carbohydrate cytochemistry of bonnet monkey (Macaca radiaca) nasal epithelium. Response to ambient levels of ozone.
MedLine Citation:
PMID:  1504469     Owner:  NLM     Status:  MEDLINE    
The main purpose of this study was to determine whether exposures to ambient levels of ozone induced changes in the carbohydrate content in the anterior nasal cavity of bonnet monkey. Monkeys were exposed to 0.00. 0.15, or 0.30 ppm of ozone for 6 or 90 days, 8 hours/day. Monkeys treated for 90 days to 0.15 or 0.30 ppm of ozone displayed damaged ciliated cells and a new cell type in their respiratory nasal epithelium, the "intermediate" cells possessing morphological characteristics of both ciliated and secretory cells. Characterization of the secretory cell carbohydrates with the PA-TCH-SP, HID-TCH-SP and LID-TCH-SP techniques indicated the existence of periodate-reactive sulfated and carboxylated polysaccharides in both treated and control monkeys. Ozone-inhalation, however, induced the appearance of a large number of mucous cells with dilated cisternae of rough endoplasmic reticulum compared to controls, which reacted negatively for sugar presence. In addition, in the respiratory epithelium ozone induced the increase of cells with intracytoplasmic lumina containing material reacted positively for sulfated and carboxylated polysaccharides.
V K Dimitriadis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Histology and histopathology     Volume:  7     ISSN:  0213-3911     ISO Abbreviation:  Histol. Histopathol.     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-09-22     Completed Date:  1992-09-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8609357     Medline TA:  Histol Histopathol     Country:  SPAIN    
Other Details:
Languages:  eng     Pagination:  479-88     Citation Subset:  IM    
Department of Genetics, Development and Molecular Biology, School of Biology, Aristotle University of Thessaloniki, Greece.
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MeSH Terms
Air Pollutants / toxicity
Carbohydrate Metabolism*
Epithelium / metabolism,  ultrastructure
Macaca radiata
Microscopy, Electron
Nasal Cavity / drug effects*,  metabolism,  ultrastructure
Ozone / administration & dosage,  toxicity*
Polysaccharides / metabolism
Reg. No./Substance:
0/Air Pollutants; 0/Polysaccharides; 10028-15-6/Ozone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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