Document Detail


Carbohydrate-containing Triton X-100 analogues for membrane protein solubilization and stabilization.
MedLine Citation:
PMID:  23377371     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Membrane protein manipulation is a challenging task owing to limited tertiary and quaternary structural stability once the protein has been removed from a lipid bilayer. Such instability can be overcome by embedding membrane proteins in detergent micelles formed from amphiphiles with carefully tuned properties. This study introduces a class of easy-to-synthesize amphiphiles, which are designated CGT (Chae's Glyco-Triton) detergents. Some of the agents are well suited for membrane protein solubilization and stabilization.
Authors:
Pil Seok Chae; Marc J Wander; Kyung Ho Cho; Philip D Laible; Samuel H Gellman
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular bioSystems     Volume:  9     ISSN:  1742-2051     ISO Abbreviation:  Mol Biosyst     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-06     Completed Date:  2013-08-16     Revised Date:  2014-04-10    
Medline Journal Info:
Nlm Unique ID:  101251620     Medline TA:  Mol Biosyst     Country:  England    
Other Details:
Languages:  eng     Pagination:  626-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Carbohydrates / chemistry*
Detergents / chemistry
Membrane Proteins / chemistry*
Micelles
Octoxynol / chemistry*
Protein Stability
Solubility
Surface-Active Agents / chemistry
Grant Support
ID/Acronym/Agency:
P01 GM075913/GM/NIGMS NIH HHS; P01GM75913/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Carbohydrates; 0/Detergents; 0/Membrane Proteins; 0/Micelles; 0/Surface-Active Agents; 9002-93-1/Octoxynol
Comments/Corrections

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