Document Detail


Carbohydrate antigen 125 predicts long-term mortality in African American patients with acute decompensated heart failure.
MedLine Citation:
PMID:  20078623     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The goal of this study was to evaluate the relation between serum levels of carbohydrate antigen 125 (CA125) and prognosis in African American (AA) patients with heart failure (HF). Little is known about the usefulness of CA125 in the AA population, which has different pathophysiology and higher prevalence of HF. The authors enrolled 172 consecutive AA patients (mean age, 55.8 years; 61.1% men) admitted with a clinical diagnosis of acute decompensated HF. CA125 was measured within 48+/-12 hours of presentation. Patients were grouped according to CA125 levels into quartiles. The median CA125 level was 16 U/mL. Serum levels of CA125 were elevated (>35 U/mL) in 58 patients (33.7%). Fifty-two patients (30.8%) died over a median follow-up period of 40 months. The CA125 threshold derived from the receiver operating characteristic curves for the prediction of mortality was 35 U/mL. In a multivariate analysis, CA125 levels >35 U/mL were found to be predictive of 40-month all-cause mortality (adjusted hazard ratio, 2.53; confidence interval, 1.40-4.59; P=.002). However, CA125 levels were not associated with 18-month HF rehospitalization. CA125 value is a strong and independent predictor of long-term mortality in AA patients admitted with a diagnosis of acute decompensated HF. Identifying a higher-risk cohort might allow for a more targeted treatment approach.
Authors:
Ibrahim N Mansour; Sirikarn Napan; M Tarek Alahdab; Thomas D Stamos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Congestive heart failure (Greenwich, Conn.)     Volume:  16     ISSN:  1751-7133     ISO Abbreviation:  Congest Heart Fail     Publication Date:    2010 Jan-Feb
Date Detail:
Created Date:  2010-01-18     Completed Date:  2010-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9714174     Medline TA:  Congest Heart Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  15-20     Citation Subset:  IM    
Copyright Information:
2009 Wiley Periodicals, Inc.
Affiliation:
Southern Illinois University School of Medicine, Department of Internal Medicine, Springfield, USA.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
African Americans*
Biological Markers / blood
CA-125 Antigen / blood*
Chemiluminescent Measurements
Comorbidity
Echocardiography
Female
Heart Failure / blood*,  ethnology,  mortality*,  ultrasonography
Humans
Male
Middle Aged
Natriuretic Peptide, Brain / blood
Prognosis
ROC Curve
Sensitivity and Specificity
Statistics, Nonparametric
Survival Analysis
Chemical
Reg. No./Substance:
0/Biological Markers; 0/CA-125 Antigen; 114471-18-0/Natriuretic Peptide, Brain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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