Document Detail


Carbohydrate does not augment exercise-induced protein accretion versus protein alone.
MedLine Citation:
PMID:  21131864     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: We tested the thesis that CHO and protein coingestion would augment muscle protein synthesis (MPS) and inhibit muscle protein breakdown (MPB) at rest and after resistance exercise.
METHODS: Nine men (age=23.0±1.9 yr, body mass index=24.2±2.1 kg·m) performed two unilateral knee extension trials (four sets×8-12 repetitions to failure) followed by consumption of 25 g of whey protein (PRO) or 25 g of whey protein plus 50 g of maltodextrin (PRO+CARB). Muscle biopsies and stable isotope methodology were used to measure MPS and MPB.
RESULTS: The areas under the glucose and insulin curves were 17.5-fold (P<0.05) and 5-fold (P<0.05) greater, respectively, for PRO+CARB than for PRO. Exercise increased MPS and MPB (both P<0.05), but there were no differences between PRO and PRO+CARB in the rested or exercised legs. Phosphorylation of Akt was greater in the PRO+CARB than in the PRO trial (P<0.05); phosphorylations of Akt (P=0.05) and acetyl coA carboxylase-β (P<0.05) were greater after exercise than at rest. The concurrent ingestion of 50 g of CHO with 25 g of protein did not stimulate mixed MPS or inhibit MPB more than 25 g of protein alone either at rest or after resistance exercise.
CONCLUSIONS: Our data suggest that insulin is not additive or synergistic to rates of MPS or MPB when CHO is coingested with a dose of protein that maximally stimulates rates of MPS.
Authors:
Aaron W Staples; Nicholas A Burd; Daniel W D West; Katharine D Currie; Philip J Atherton; Daniel R Moore; Michael J Rennie; Maureen J Macdonald; Steven K Baker; Stuart M Phillips
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  43     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-22     Completed Date:  2011-10-28     Revised Date:  2012-06-07    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1154-61     Citation Subset:  IM; S    
Affiliation:
Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adult
Dietary Carbohydrates / administration & dosage*,  metabolism
Dietary Proteins / administration & dosage,  metabolism
Eating
Exercise*
Humans
Insulin / blood
Knee / physiology
Male
Milk Proteins / administration & dosage,  metabolism
Muscle Proteins / biosynthesis,  metabolism*
Muscle, Skeletal / metabolism*
Polysaccharides / administration & dosage,  metabolism
Protein Kinases / metabolism
Proto-Oncogene Proteins c-akt / metabolism
Young Adult
Chemical
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Dietary Proteins; 0/Insulin; 0/Milk Proteins; 0/Muscle Proteins; 0/Polysaccharides; 0/whey protein; 9050-36-6/maltodextrin; EC 2.7.-/Protein Kinases; EC 2.7.11.1/Proto-Oncogene Proteins c-akt; EC 2.7.11.27/(acetyl-CoA carboxylase) kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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