| Carbohydrate Does Not Augment Exercise-Induced Protein Accretion versus Protein Alone. | |
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MedLine Citation:
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PMID: 21131864 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE: : We tested the thesis that CHO and protein coingestion would augment muscle protein synthesis (MPS) and inhibit muscle protein breakdown (MPB) at rest and after resistance exercise. METHODS: : Nine men (age = 23.0 ± 1.9 yr, body mass index = 24.2 ± 2.1 kg·m) performed two unilateral knee extension trials (four sets × 8-12 repetitions to failure) followed by consumption of 25 g of whey protein (PRO) or 25 g of whey protein plus 50 g of maltodextrin (PRO + CARB). Muscle biopsies and stable isotope methodology were used to measure MPS and MPB. RESULTS: : The areas under the glucose and insulin curves were 17.5-fold (P < 0.05) and 5-fold (P < 0.05) greater, respectively, for PRO + CARB than for PRO. Exercise increased MPS and MPB (both P < 0.05), but there were no differences between PRO and PRO + CARB in the rested or exercised legs. Phosphorylation of Akt was greater in the PRO + CARB than in the PRO trial (P < 0.05); phosphorylations of Akt (P = 0.05) and acetyl coA carboxylase-β (P < 0.05) were greater after exercise than at rest. The concurrent ingestion of 50 g of CHO with 25 g of protein did not stimulate mixed MPS or inhibit MPB more than 25 g of protein alone either at rest or after resistance exercise. CONCLUSIONS: : Our data suggest that insulin is not additive or synergistic to rates of MPS or MPB when CHO is coingested with a dose of protein that maximally stimulates rates of MPS. |
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Authors:
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Aaron W Staples; Nicholas A Burd; Daniel W D West; Katharine D Currie; Philip J Atherton; Daniel R Moore; Michael J Rennie; Maureen J Macdonald; Steven K Baker; Stuart M Phillips |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medicine and science in sports and exercise Volume: 43 ISSN: 1530-0315 ISO Abbreviation: Med Sci Sports Exerc Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-06-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: United States |
Other Details:
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Languages: eng Pagination: 1154-61 Citation Subset: IM; S |
Affiliation:
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1Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, CANADA; 2School of Graduate Entry Medicine and Health, City Hospital, University of Nottingham, Derby, UNITED KINGDOM; and 3Michael G. DeGroote School of Medicine, Department of Neurology, McMaster University, Hamilton, Ontario, CANADA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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