| Carbocisteine normalizes the viscous property of mucus through regulation of fucosylated and sialylated sugar chain on airway mucins. | |
| | |
MedLine Citation:
|
PMID: 20553908 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Almost all of fucose and sialic acid in mucus are found on the mucus glycoproteins (mucins), and these sugar components on mucins are known to be associated with the viscous property of mucus. We have reported some aspects of carbocisteine, a mucoregulatory drug, correcting fucose and sialic acid contents in mucus. At present, carbocisteine's expectorant action of airway mucus is postulated to involve - the regulation of fucose and sialic acid contents on mucins. However little information is available about the relationship between the viscosity and sugar contents on mucins when treated with carbocisteine. To investigate further the mechanism behind the action of carbocisteine, the present study prepared MUC5AC fusion protein which has tandem repeat regions associated with MUC5AC, and evaluated the effects of carbocisteine on tumor necrosis factor (TNF)-alpha-induced increases of mucus viscosity and sialyl-Lewis x-epitopes antigen, an antigen which consists of fucosylated and sialylated sugar chains on the MUC5AC fusion proteins. Carbocisteine inhibited the TNF-alpha-induced increases of the viscosity and sialyl-Lewis x-epitopes on MUC5AC fusion protein. These findings suggest that carbocisteine may normalize the viscosity of mucus through "balancing" of fucose and sialic acid contents on airway mucins. |
| | |
Authors:
|
Yuji Ishibashi; Goh Takayama; Yoshio Inouye; Akiyoshi Taniguchi |
Related Documents
:
|
7682418 - Inhibition of the adenylylation of liver plasma membrane-bound proteins by plant and ma... 3208248 - Synthesis and characterization of lyso-gm3 (ii3neu5ac lactosyl sphingosine), de-n-acety... 18509108 - Multifunctionality of campylobacter jejuni sialyltransferase cstii: characterization of... 2458008 - Histochemistry of glycoconjugates in the goat nasolabial skin with special reference to... 21184438 - Heterologous production of polyunsaturated fatty acids in saccharomyces cerevisiae caus... 62478 - Intensification of cobaltous sulphide precipitate in frog nervous tissue. |
Publication Detail:
|
Type: Journal Article Date: 2010-06-09 |
Journal Detail:
|
Title: European journal of pharmacology Volume: 641 ISSN: 1879-0712 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-07-15 Completed Date: 2011-01-31 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 226-8 Citation Subset: IM |
Copyright Information:
|
Copyright (c) 2010 Elsevier B.V. All rights reserved. |
Affiliation:
|
Advanced Medical Materials Group, Biomaterials Center, National Institute for Materials Science, Ibaraki, Japan. yuuji.ishibashi@mb.kyorin-pharm.co.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Carbocysteine
/
pharmacology* Carbohydrates / chemistry, physiology* Cell Line, Tumor Epitopes Expectorants / pharmacology Fucose / metabolism Humans Lung Neoplasms / pathology Mucins / genetics, metabolism* Mucus / metabolism* N-Acetylneuraminic Acid / metabolism Oligosaccharides / metabolism Recombinant Fusion Proteins / isolation & purification, metabolism Respiratory System / metabolism Tumor Necrosis Factor-alpha / metabolism, pharmacology Viscosity |
| Chemical | |
Reg. No./Substance:
|
0/5-acetylneuraminyl-(2-3)-galactosyl-(1-4)-(fucopyranosyl-(1-3))-N-acetylglucosamine; 0/Carbohydrates; 0/Epitopes; 0/Expectorants; 0/Mucins; 0/Oligosaccharides; 0/Recombinant Fusion Proteins; 0/Tumor Necrosis Factor-alpha; 131-48-6/N-Acetylneuraminic Acid; 2387-59-9/Carbocysteine; 3713-31-3/Fucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Resveratrol modulates RTX toxin-induced cytotoxicity through interference in adhesion and toxin prod...
Next Document: Trichostatin A prevents TGF-beta1-induced apoptosis by inhibiting ERK activation in human renal tubu...