Document Detail


Carbocisteine normalizes the viscous property of mucus through regulation of fucosylated and sialylated sugar chain on airway mucins.
MedLine Citation:
PMID:  20553908     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Almost all of fucose and sialic acid in mucus are found on the mucus glycoproteins (mucins), and these sugar components on mucins are known to be associated with the viscous property of mucus. We have reported some aspects of carbocisteine, a mucoregulatory drug, correcting fucose and sialic acid contents in mucus. At present, carbocisteine's expectorant action of airway mucus is postulated to involve - the regulation of fucose and sialic acid contents on mucins. However little information is available about the relationship between the viscosity and sugar contents on mucins when treated with carbocisteine. To investigate further the mechanism behind the action of carbocisteine, the present study prepared MUC5AC fusion protein which has tandem repeat regions associated with MUC5AC, and evaluated the effects of carbocisteine on tumor necrosis factor (TNF)-alpha-induced increases of mucus viscosity and sialyl-Lewis x-epitopes antigen, an antigen which consists of fucosylated and sialylated sugar chains on the MUC5AC fusion proteins. Carbocisteine inhibited the TNF-alpha-induced increases of the viscosity and sialyl-Lewis x-epitopes on MUC5AC fusion protein. These findings suggest that carbocisteine may normalize the viscosity of mucus through "balancing" of fucose and sialic acid contents on airway mucins.
Authors:
Yuji Ishibashi; Goh Takayama; Yoshio Inouye; Akiyoshi Taniguchi
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Publication Detail:
Type:  Journal Article     Date:  2010-06-09
Journal Detail:
Title:  European journal of pharmacology     Volume:  641     ISSN:  1879-0712     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-07-15     Completed Date:  2011-01-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  226-8     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier B.V. All rights reserved.
Affiliation:
Advanced Medical Materials Group, Biomaterials Center, National Institute for Materials Science, Ibaraki, Japan. yuuji.ishibashi@mb.kyorin-pharm.co.jp
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MeSH Terms
Descriptor/Qualifier:
Carbocysteine / pharmacology*
Carbohydrates / chemistry,  physiology*
Cell Line, Tumor
Epitopes
Expectorants / pharmacology
Fucose / metabolism
Humans
Lung Neoplasms / pathology
Mucins / genetics,  metabolism*
Mucus / metabolism*
N-Acetylneuraminic Acid / metabolism
Oligosaccharides / metabolism
Recombinant Fusion Proteins / isolation & purification,  metabolism
Respiratory System / metabolism
Tumor Necrosis Factor-alpha / metabolism,  pharmacology
Viscosity
Chemical
Reg. No./Substance:
0/5-acetylneuraminyl-(2-3)-galactosyl-(1-4)-(fucopyranosyl-(1-3))-N-acetylglucosamine; 0/Carbohydrates; 0/Epitopes; 0/Expectorants; 0/Mucins; 0/Oligosaccharides; 0/Recombinant Fusion Proteins; 0/Tumor Necrosis Factor-alpha; 131-48-6/N-Acetylneuraminic Acid; 2387-59-9/Carbocysteine; 3713-31-3/Fucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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