| Carbocisteine can scavenge reactive oxygen species in vitro. | |
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MedLine Citation:
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PMID: 19144049 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVE: Reactive oxygen species (ROS) play an important role in the pathogenesis of various respiratory diseases. Carbocisteine, a mucoregulatory drug, is used in the treatment of several disease states but little information is available about its scavenger effects on ROS. The present study was designed to examine the scavenger effects of carbocisteine on ROS. METHODS: The oxidation-reduction potential of carbocisteine was measured, and its scavenger effects on hypochlorous acid (HOCl), hydrogen peroxide (H(2)O(2)), hydroxyl radical (OH(*)) and peroxynitrite (ONOO(-)) were examined in cell-free conditions. The effects of carbocisteine on ROS generated from rat neutrophils, intracellular oxidative stress and release of inflammatory cytokines (IL-8 and IL-6) from IL-1 beta-induced airway epithelial cells, NCI-H292 cells, were investigated. RESULTS: Carbocisteine provided a reducing stage and showed scavenger effects on H(2)O(2), HOCl, OH(*) and ONOO(-) in cell-free conditions. Carbocisteine inhibited ROS generation from rat neutrophils, intracellular oxidative stress and release of IL-8 and IL-6 from NCI-H292 cells. N-acetyl-L-cysteine, a radical scavenger, also inhibited these events related to ROS as well as carbocisteine. CONCLUSIONS: These results suggest that carbocisteine could exert anti-inflammatory and anti-oxidant effects through directly scavenging ROS in addition to its previously known mucoregulatory effect. |
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Authors:
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Hisashi Nogawa; Yuji Ishibashi; Akitsu Ogawa; Kayoko Masuda; Takeshi Tsubuki; Tomoko Kameda; Shigeki Matsuzawa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Respirology (Carlton, Vic.) Volume: 14 ISSN: 1440-1843 ISO Abbreviation: Respirology Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-01-15 Completed Date: 2009-05-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9616368 Medline TA: Respirology Country: Australia |
Other Details:
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Languages: eng Pagination: 53-9 Citation Subset: IM |
Affiliation:
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Research Center, Kyorin Pharmaceutical Co., Ltd, Shimotsuga-gun, Tochigi, Japan. hisashi.nogawa@mb.kyorin-pharm.co.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bronchitis, Chronic / drug therapy Carbocysteine / chemistry, pharmacology* Cells, Cultured Expectorants / chemistry, pharmacology* Free Radical Scavengers / chemistry, pharmacology* Humans Lung Diseases / drug therapy* Oxidation-Reduction Pulmonary Disease, Chronic Obstructive / drug therapy Pulmonary Emphysema / drug therapy Rats Rats, Wistar Reactive Oxygen Species / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Expectorants; 0/Free Radical Scavengers; 0/Reactive Oxygen Species; 2387-59-9/Carbocysteine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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