Document Detail


Carbenoxolone and triterpenoids inhibited mucin secretion from airway epithelial cells.
MedLine Citation:
PMID:  17262888     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study investigated whether carbenoxolone, oleanolic acid and ursolic acid affect ATP-induced mucin secretion from cultured airway epithelial cells. Confluent primary hamster tracheal surface epithelial (HTSE) cells were metabolically radiolabeled using (3)H-glucosamine for 24 h and chased for 30 min in the presence of varying concentrations of each agent to assess the effects on (3)H-mucin secretion. The possible cytotoxicity of each agent was investigated with a lactate dehydrogenase assay. The results were as follows: (1) carbenoxolone, oleanolic acid and ursolic acid significantly inhibited the secretion of airway mucin induced by ATP; (2) none of the compounds showed significant cytotoxicity at any concentration. This result suggests that carbenoxolone, oleanolic acid and ursolic acid can regulate 'mucin secretion induced by ATP'--phenomenon simulating mucus overproduction from inflamed airway epithelial cells--y directly acting on airway mucin-secreting cells.
Authors:
Ho Jin Heo; Cheolsu Kim; Hyun Jae Lee; Young Sik Kim; Sam Sik Kang; Un Kyo Seo; Yun Hee Kim; Yang Chun Park; Jeong Ho Seok; Choong Jae Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  21     ISSN:  0951-418X     ISO Abbreviation:  Phytother Res     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-24     Completed Date:  2007-07-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  462-5     Citation Subset:  IM    
Copyright Information:
Copyright 2007 John Wiley & Sons, Ltd.
Affiliation:
Department of Pharmacology, College of Medicine, Chungnam National University, Daejeon, Korea.
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / metabolism,  physiology
Animals
Carbenoxolone / pharmacology*
Cells, Cultured
Cricetinae
Epithelial Cells / drug effects*,  metabolism
Mucins / secretion*
Oleanolic Acid / pharmacology*
Respiratory Mucosa / drug effects*,  metabolism
Triterpenes / pharmacology*
Chemical
Reg. No./Substance:
0/Mucins; 0/Triterpenes; 508-02-1/Oleanolic Acid; 56-65-5/Adenosine Triphosphate; 5697-56-3/Carbenoxolone; 77-52-1/ursolic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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