Document Detail

Carbaprostacyclin, a PPARdelta agonist, ameliorates excess lipid accumulation in diabetic rat placentas.
MedLine Citation:
PMID:  20338185     Owner:  NLM     Status:  MEDLINE    
AIMS: Maternal diabetes impairs placental development and metabolism. Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear receptors relevant in metabolic homeostasis. We investigated the concentrations of PPARdelta and its endogenous agonist prostacyclin (PGI2), as well as the effects of carbaprostacylin (cPGI(2,) a PPARdelta agonist) on lipid metabolism in placentas from control and streptozotocin-induced diabetic rats on day 13.5 of gestation. MAIN METHODS: The placentas were explanted to evaluate PPARdelta expression and PGI2 concentrations, and cultured with cPGI2 for further analysis of lipid metabolism (concentrations and (14)C-acetate derived synthesis of triglycerides, cholesteryl esters, phospholipids, cholesterol and free fatty acids; release of glycerol and lipid peroxidation). KEY FINDINGS: Reduced PGI2 concentrations were found in the placentas from diabetic rats when compared to controls. cPGI2 additions reduced the concentrations and synthesis of several lipid species, increased lipid catabolism and reduced lipid peroxidation in the placenta. These effects were more marked in diabetic tissues, which presented alterations in the lipid metabolic parameters evaluated. cPGI2 additions increased placental PPARdelta and acyl-CoA oxidase expression, which are changes possibly involved in the catabolic effects observed. SIGNIFICANCE: The present study reveals the capability of cPGI2 to regulate placental lipid metabolism and PPARdelta expression, and suggests that preserving appropriate PGI2 concentrations in the placenta may help to metabolize maternal derived lipid overload in diabetic gestations.
Melisa Kurtz; Evangelina Capobianco; Nora Mart?nez; Jimena Fern?ndez; Romina Higa; Ver?nica White; Alicia Jawerbaum
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-22
Journal Detail:
Title:  Life sciences     Volume:  86     ISSN:  1879-0631     ISO Abbreviation:  Life Sci.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-11     Completed Date:  2010-05-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  781-90     Citation Subset:  IM    
Laboratory of Reproduction and Metabolism, CEFYBO-CONICET, School of Medicine, University of Buenos Aires, Paraguay Buenos Aires, Argentina.
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MeSH Terms
Acyl-CoA Oxidase / metabolism
Diabetes Mellitus, Experimental / complications,  drug therapy
Epoprostenol / analogs & derivatives*,  analysis,  pharmacology
Glycerol / analysis
Lipid Metabolism / drug effects
Lipid Peroxidation / drug effects
Lipids / analysis*
PPAR delta / agonists*,  analysis
Placenta / chemistry,  drug effects*
Placenta Diseases / drug therapy,  etiology
Pregnancy in Diabetics / drug therapy*,  metabolism
Rats, Wistar
Reg. No./Substance:
0/Lipids; 0/PPAR delta; 0/carbaprostacyclin; 35121-78-9/Epoprostenol; 56-81-5/Glycerol; EC Oxidase

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