Document Detail


Carbanions from decarboxylation of orotate analogs: stability and mechanistic implications.
MedLine Citation:
PMID:  17400276     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pKa's of the 6-CH groups of 1,3-dimethyluracil, N-methyl-2-pyridone, and N-methyl-4-pyridone were determined through their reactions with bases derived from carbon acids with known pKa and the reactions of their corresponding carbanions with the carbon acids. No correlation between the stability of the carbanions and the rate of decarboxylation of corresponding carboxylic acids was found.
Authors:
Fong Ying Yeoh; Roxanne R Cuasito; Christina C Capule; Freeman M Wong; Weiming Wu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-04-02
Journal Detail:
Title:  Bioorganic chemistry     Volume:  35     ISSN:  0045-2068     ISO Abbreviation:  Bioorg. Chem.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-03     Completed Date:  2007-09-05     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  1303703     Medline TA:  Bioorg Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  338-43     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anions / chemistry*
Carboxylic Acids / chemistry
Decarboxylation
Orotic Acid / analogs & derivatives*,  chemistry
Pyridones / chemistry
Grant Support
ID/Acronym/Agency:
5 S06 GM52588/GM/NIGMS NIH HHS; S06 GM052588/GM/NIGMS NIH HHS; S06 GM052588-140008/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Anions; 0/Carboxylic Acids; 0/Pyridones; 61H4T033E5/Orotic Acid
Comments/Corrections

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