Document Detail


Carbamylation distributions in extracorporeal treatment of sickle cell anemia.
MedLine Citation:
PMID:  650059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The extracorporeal exposure of blood from patients with sickle cell anemia results in the binding of different amounts of cyanate to the hemoglobin of individual erythrocytes. This distribution pattern of carbamylated hemoglobin may affect the efficacy of treatment. A computer model has been developed to predict the carbamylation distribution attained in batch ex vivo exposures. In addition, an autoradiographic technique has been developed whereby the actual distribution pattern of carbamylated hemoglobin in small volumes of blood can be determined. Agreement was demonstrated between the computer model predictions and the actual distribution patterns. The model was applied to published results of extracorporeal treatments of sickle cell patients, and profiles of loading were compared. With the use of such approaches it will be possible to test the importance of the erythrocyte distribution of carbamylated hemoglobin on clinical effects and to design protocols to achieve an optimum distribution. The procedure may be adapted to the distribution of other therapeutic agents as they become available.
Authors:
D A Uvelli; L C Agodoa; A L Babb
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of laboratory and clinical medicine     Volume:  91     ISSN:  0022-2143     ISO Abbreviation:  J. Lab. Clin. Med.     Publication Date:  1978 Jun 
Date Detail:
Created Date:  1978-07-26     Completed Date:  1978-07-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375375     Medline TA:  J Lab Clin Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  939-47     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Anemia, Sickle Cell / blood,  therapy*
Chemical Phenomena
Chemistry
Computers
Cyanates / blood*
Erythrocytes / metabolism*
Extracorporeal Circulation
Hemoglobins / metabolism*
Humans
Models, Biological
Chemical
Reg. No./Substance:
0/Cyanates; 0/Hemoglobins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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