Document Detail

Carbamylated hemoglobin in prerenal azotemia.
MedLine Citation:
PMID:  8569946     Owner:  NLM     Status:  MEDLINE    
Carbamylated hemoglobin (Carb Hb) levels were measured in 16 patients with a documented transient rise in BUN due to prerenal azotemia, in whom BUN levels before and after the episode were normal. They were compared with 13 controls. Carb Hb was expressed as carbamyl valine concentrations, which were significantly higher in the patients (166 micrograms/g Hb) than in controls (95.3 micrograms/g Hb, p < 0.01). The mean maximum BUN level in the patients was 51.8 +/- 23.9 mg/dl. There was a significant correlation between the product of mean BUN level times the number of days of BUN elevation, and the Carb Hb level (r = 0.5197; p < 0.05). There was no correlation between Carb Hb and either mean BUN level or maximum BUN level. Elevated Carb Hb was seen after a minimum of 4 days' BUN elevation. Four patients had no elevation of Carb Hb despite elevated BUN levels. Conclusion: Carb Hb may be elevated after a minimum of 4 days' transient BUN elevation; Carb Hb is not useful in differentiating between mild acute renal failure and prerenal azotemia.
J M Frazao; R H Barth; G M Berlyne
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nephron     Volume:  71     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1995  
Date Detail:
Created Date:  1996-03-05     Completed Date:  1996-03-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  153-5     Citation Subset:  IM    
Department of Nephrology, Department of Veterans Affairs Medical Center, Brooklyn, NY 11209, USA.
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MeSH Terms
Aged, 80 and over
Blood Urea Nitrogen
Carbamates / blood*
Creatinine / blood
Diagnosis, Differential
Hemoglobins / metabolism*
Kidney Diseases / blood*
Kidney Failure / diagnosis
Middle Aged
Time Factors
Uremia / blood*,  diagnosis
Valine / metabolism
Reg. No./Substance:
0/Carbamates; 0/Hemoglobins; 60-27-5/Creatinine; 7004-03-7/Valine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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