Document Detail

Carbamazepine-induced drug reaction with eosinophilia and systemic symptoms syndrome in a 35-year-old man with epilepsy.
MedLine Citation:
PMID:  18836349     Owner:  NLM     Status:  MEDLINE    
The drug reaction with eosinophilia and systemic symptoms syndrome describes a hypersensitivity reaction to a number of drugs. It is characterized by a triad of fever, rash, and internal organ involvement. Carbamazepine is suspected to be the cause of the drug reaction with eosinophilia and systemic symptoms syndrome in this young man who presented with fulminant hepatitis and an exfoliating rash 8 weeks after starting carbamazepine. Symptoms gradually resolved after stopping carbamazepine and starting systemic steroids.Because we encountered only a few similar cases in the literature, we wish to highlight the importance of recognizing these symptoms as a syndrome that can be fatal, especially if not recognized early.
Claudia Fsadni; Peter Fsadni; Tonio Piscopo; Charles Mallia Azzopardi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical neuropharmacology     Volume:  31     ISSN:  1537-162X     ISO Abbreviation:  Clin Neuropharmacol     Publication Date:    2008 Sep-Oct
Date Detail:
Created Date:  2008-10-06     Completed Date:  2009-05-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7607910     Medline TA:  Clin Neuropharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  295-8     Citation Subset:  IM    
Infectious Diseases Unit, St Luke's Hospital, Gwardamangia, Malta.
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MeSH Terms
Carbamazepine / adverse effects*
Eosinophilia / chemically induced*,  diagnosis*,  physiopathology
Epilepsy / drug therapy*,  physiopathology
Reg. No./Substance:

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