Document Detail

Carbamazepine-erythromycin interaction. Case studies and clinical significance.
MedLine Citation:
PMID:  3945037     Owner:  NLM     Status:  MEDLINE    
Because of significant and seemingly haphazard fluctuations in serum carbamazepine concentrations, we decided to investigate the possible link between erythromycin administration and potential changes in serum carbamazepine concentration. We studied four cases involving this combination. In every case, serum carbamazepine concentrations either rose dramatically (doubled or tripled previous steady-state concentrations) or dropped precipitously once erythromycin therapy was discontinued. In all cases, we report serum carbamazepine concentrations obtained before, during, and after concurrent erythromycin administration. We conclude that the combination of erythromycin and carbamazepine represents a clinically significant drug interaction and should be avoided where possible.
B A Wroblewski; W D Singer; J Whyte
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  JAMA     Volume:  255     ISSN:  0098-7484     ISO Abbreviation:  JAMA     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-03-21     Completed Date:  1986-03-21     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1165-7     Citation Subset:  AIM; IM    
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MeSH Terms
Carbamazepine / blood*
Drug Interactions
Erythromycin / adverse effects*
Fluorescence Polarization
Reg. No./Substance:
33CM23913M/Carbamazepine; 63937KV33D/Erythromycin

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