Document Detail


Carbamazepine enhances brain production of kynurenic acid in vitro.
MedLine Citation:
PMID:  15364012     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Disturbed formation of kynurenic acid, an endogenous antagonist of glutamate ionotropic receptors, might contribute to the pathogenesis of seizures. Here, the effect of anticonvulsant drug, carbamazepine on the production of kynurenic acid was studied. Carbamazepine (0.5-3 mM) enhanced kynurenic acid synthesis in rat cortical slices and also increased the activity of kynurenine aminotransferase (KAT) I at 0.1-3.0 mM concentration. Thus, anticonvulsant drugs, such as carbamazepine, might act partially via stimulation of kynurenic acid production.
Authors:
Tomasz Kocki; Janusz Kocki; Marian Wielosz; Waldemar A Turski; Ewa M Urbanska
Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  498     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-09-14     Completed Date:  2005-02-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  325-6     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Toxicology, Skubiszewski Medical University, Jaczewskiego 8, 20-090 Lublin, Poland.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Anticonvulsants / pharmacology*
Brain / drug effects*,  enzymology,  metabolism
Carbamazepine / pharmacology*
Cerebral Cortex / drug effects,  enzymology,  metabolism
Chromatography, High Pressure Liquid
Dose-Response Relationship, Drug
Isoenzymes / metabolism
Kynurenic Acid / metabolism*
Kynurenine / pharmacology
Male
Rats
Rats, Wistar
Transaminases / metabolism
Chemical
Reg. No./Substance:
0/Anticonvulsants; 0/Isoenzymes; 298-46-4/Carbamazepine; 343-65-7/Kynurenine; 492-27-3/Kynurenic Acid; EC 2.6.1.-/Transaminases; EC 2.6.1.7/kynurenine-oxoglutarate transaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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