| Carbamazepine enhances brain production of kynurenic acid in vitro. | |
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MedLine Citation:
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PMID: 15364012 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Disturbed formation of kynurenic acid, an endogenous antagonist of glutamate ionotropic receptors, might contribute to the pathogenesis of seizures. Here, the effect of anticonvulsant drug, carbamazepine on the production of kynurenic acid was studied. Carbamazepine (0.5-3 mM) enhanced kynurenic acid synthesis in rat cortical slices and also increased the activity of kynurenine aminotransferase (KAT) I at 0.1-3.0 mM concentration. Thus, anticonvulsant drugs, such as carbamazepine, might act partially via stimulation of kynurenic acid production. |
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Authors:
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Tomasz Kocki; Janusz Kocki; Marian Wielosz; Waldemar A Turski; Ewa M Urbanska |
Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of pharmacology Volume: 498 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-09-14 Completed Date: 2005-02-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 325-6 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Toxicology, Skubiszewski Medical University, Jaczewskiego 8, 20-090 Lublin, Poland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Anticonvulsants / pharmacology* Brain / drug effects*, enzymology, metabolism Carbamazepine / pharmacology* Cerebral Cortex / drug effects, enzymology, metabolism Chromatography, High Pressure Liquid Dose-Response Relationship, Drug Isoenzymes / metabolism Kynurenic Acid / metabolism* Kynurenine / pharmacology Male Rats Rats, Wistar Transaminases / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Isoenzymes; 298-46-4/Carbamazepine; 343-65-7/Kynurenine; 492-27-3/Kynurenic Acid; EC 2.6.1.-/Transaminases; EC 2.6.1.7/kynurenine-oxoglutarate transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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