Document Detail

'Captopril test', with blood pressure and peripheral renin as response variables in hypertensive patients with suspected renal artery stenosis.
MedLine Citation:
PMID:  8551488     Owner:  NLM     Status:  MEDLINE    
In forty six hypertensive patients in whom a high level of clinical suspicion for renovascular hypertension was present on the basis of clinical clues, a captopril test was performed with either 25 mg of captopril or placebo on 2 separate days to determine prospectively the value of the captopril test. Blood pressure (BP) and peripheral renin were used as response variables. All patients had discontinued their anti-hypertensive medication and were not salt depleted. In all patients selective renal angiography was performed irrespective of the results of the captopril test. Twenty patients proved to have uni- or bilateral renal artery stenosis (RAS) giving a prevalence of 43%. After the placebo and after captopril there were no significant changes (absolute or proportional) in BP values between patients with essential hypertension or RAS, either for all measurements or if only the fall in BP was taken into account. The receiver operator characteristic curves of both baseline and post-captopril peripheral renin levels indicate that the captopril test does not discriminate appropriately between patients with essential hypertension and RAS. Therefore, we would not advise the use of the captopril test as a screening test for RAS in hypertensive patients in whom a high level of clinical suspicion for RAS is already present.
G Schreij; P N van Es; P M Schiffers; A T Lavrijssen; P W de Leeuw
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of human hypertension     Volume:  9     ISSN:  0950-9240     ISO Abbreviation:  J Hum Hypertens     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1996-02-20     Completed Date:  1996-02-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  741-6     Citation Subset:  IM    
Department of Internal Medicine, University Hospital, Maastricht, The Netherlands.
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MeSH Terms
Aldosterone / blood
Angiotensin-Converting Enzyme Inhibitors / administration & dosage,  diagnostic use*
Blood Pressure Determination
Captopril / administration & dosage,  diagnostic use*
Diagnosis, Differential
Hypertension / blood,  diagnosis*
Hypertension, Renal / blood,  diagnosis
Immunoradiometric Assay
Middle Aged
Prospective Studies
Renal Artery Obstruction / blood,  diagnosis*
Renin / blood*,  drug effects
Sensitivity and Specificity
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 52-39-1/Aldosterone; 62571-86-2/Captopril; EC

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