Document Detail

Captopril and stress-induced hypertension in the borderline hypertensive rat.
MedLine Citation:
PMID:  8866900     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Daily exposure to air-jet stress (AJS) causes sustained elevations of blood pressure in borderline hypertensive rats (BHR). It is known that the renin-angiotensin system is activated during episodes of behavioral stress, and the purpose of this study was to assess the involvement of renin-angiotensin system in the development of stress-induced hypertension in the BHR. DESIGN: Four groups of 8- and 9-week-old rats were studied: they received, respectively, oral captopril and AJS; oral captopril without AJS; AJS without captopril; and neither AJS nor captopril. METHODS: After 10 days of AJS and captopril conditions, femoral and jugular catheters were implanted for the measurement of mean arterial pressure and pressor responses to norepinephrine and tyramine. Blood samples were collected for the measurement of norepinephrine and plasma renin activity. RESULTS: Ten days of AJS caused a significant elevation of blood pressure in BHR exposed to AJS without receiving captopril but not in those animals given captopril concurrently with AJS. Circulating norepinephrine and blood pressure responses to exogenous norepinephrine and tyramine were similar across the four groups. Plasma renin activity was highest in BHR given captopril, and was significantly elevated during an acute episode of AJS. CONCLUSIONS: The renin-angiotensin system may be important in the development of stress-induced hypertension in the BHR.
S C Coste; Y Qi; V L Brooks; D A McCarron; D C Hatton
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of hypertension     Volume:  13     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1997-01-03     Completed Date:  1997-01-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1391-98     Citation Subset:  IM    
Department of Medical Psychology, Oregon Health Sciences University, Portland 97201-3098, USA.
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MeSH Terms
Blood Pressure / drug effects
Captopril / pharmacology*
Hybridization, Genetic
Hypertension / blood,  physiopathology*
Norepinephrine / blood,  pharmacology
Physical Stimulation
Rats, Inbred SHR
Rats, Inbred WKY
Renin / blood
Stress, Physiological / complications*
Tyramine / pharmacology
Grant Support
Reg. No./Substance:
51-41-2/Norepinephrine; 51-67-2/Tyramine; 62571-86-2/Captopril; EC

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