Document Detail

Captopril and salt subtraction to treat "uncontrollable" hypertension in haemodialysis patients.
MedLine Citation:
PMID:  232915     Owner:  NLM     Status:  MEDLINE    
Eight patients on chronic haemodialysis for six months to 7 years with hypertension resistant to ultrafiltration and antihypertensive therapy, received Captopril (SQ 14, 225) an orally active inhibitor of converting enzyme. With this therapy, blood pressure was controlled in the 4 patients with the highest plasma renin activity. In the other 4, this treatment had to be supplemented with "isovolumetric salt subtraction", i.e. following conventional dialysis, 1-2 litres of ultrafiltrate were replaced by an equal volume of 5% glucose. The slight hyponatraemia induced by this procedure (plasma sodium 128mmol/L) was well tolerated. This procedure allows the removal of an excess of body sodium and seems to be effective even when conventional ultrafiltration during dialysis has failed. Administration of Captopril either alone or combined with "isovolumetric salt subtraction" induced good control of blood pressure in all 8 patients.
J P Wauters; B Waeber; H R Brunner; G A Turini; J P Guignard; H Gavras
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association     Volume:  16     ISSN:  0071-2736     ISO Abbreviation:  Proc Eur Dial Transplant Assoc     Publication Date:  1979  
Date Detail:
Created Date:  1980-09-23     Completed Date:  1980-09-23     Revised Date:  2008-02-21    
Medline Journal Info:
Nlm Unique ID:  0355210     Medline TA:  Proc Eur Dial Transplant Assoc     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  610-7     Citation Subset:  IM    
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors
Blood Glucose
Blood Pressure / drug effects
Captopril / therapeutic use*
Hypertension / drug therapy*
Middle Aged
Osmolar Concentration
Proline / analogs & derivatives*
Renal Dialysis*
Renin / blood
Salts / therapeutic use*
Sodium / blood
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Blood Glucose; 0/Salts; 147-85-3/Proline; 62571-86-2/Captopril; 7440-23-5/Sodium; EC

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