| Captopril for refractory hypertension in patients with impaired renal function. | |
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MedLine Citation:
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PMID: 3886905 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The use of captopril in 19 patients with renal parenchymal disease and refractory hypertension was studied for a mean period of 12 months. There was a significant reduction in the systolic and diastolic blood pressures, with a reduction in the mean arterial pressure of 29 mmHg. The mean maintenance dose of captopril was 142 mg daily in three divided doses. All but one of the patients required a diuretic for satisfactory blood pressure control and 3 patients were also given a beta-blocker. In all patients a simplification of the previous therapeutic regimen was achieved. A significant rise in serum creatinine was noted in 2 patients, one of whom had to be withdrawn from the study. Despite the presence of renal functional impairment, proteinuria did not occur de novo nor did established proteinuria increase. Leukopenia was noted in any of the patients in this group. |
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Authors:
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M S Laher; P O'Regan; J F O'Donohoe; T B Counihan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the Royal Society of Medicine Volume: 78 ISSN: 0141-0768 ISO Abbreviation: J R Soc Med Publication Date: 1985 May |
Date Detail:
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Created Date: 1985-06-17 Completed Date: 1985-06-17 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7802879 Medline TA: J R Soc Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 367-72 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure
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drug effects Captopril / administration & dosage, adverse effects, therapeutic use* Drug Administration Schedule Female Humans Hypertension, Renal / drug therapy* Hypertension, Renovascular / drug therapy Male Middle Aged Proline / analogs & derivatives* |
| Chemical | |
Reg. No./Substance:
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147-85-3/Proline; 62571-86-2/Captopril |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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