Document Detail


Captopril for refractory hypertension in patients with impaired renal function.
MedLine Citation:
PMID:  3886905     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The use of captopril in 19 patients with renal parenchymal disease and refractory hypertension was studied for a mean period of 12 months. There was a significant reduction in the systolic and diastolic blood pressures, with a reduction in the mean arterial pressure of 29 mmHg. The mean maintenance dose of captopril was 142 mg daily in three divided doses. All but one of the patients required a diuretic for satisfactory blood pressure control and 3 patients were also given a beta-blocker. In all patients a simplification of the previous therapeutic regimen was achieved. A significant rise in serum creatinine was noted in 2 patients, one of whom had to be withdrawn from the study. Despite the presence of renal functional impairment, proteinuria did not occur de novo nor did established proteinuria increase. Leukopenia was noted in any of the patients in this group.
Authors:
M S Laher; P O'Regan; J F O'Donohoe; T B Counihan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the Royal Society of Medicine     Volume:  78     ISSN:  0141-0768     ISO Abbreviation:  J R Soc Med     Publication Date:  1985 May 
Date Detail:
Created Date:  1985-06-17     Completed Date:  1985-06-17     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802879     Medline TA:  J R Soc Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  367-72     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Blood Pressure / drug effects
Captopril / administration & dosage,  adverse effects,  therapeutic use*
Drug Administration Schedule
Female
Humans
Hypertension, Renal / drug therapy*
Hypertension, Renovascular / drug therapy
Male
Middle Aged
Proline / analogs & derivatives*
Chemical
Reg. No./Substance:
147-85-3/Proline; 62571-86-2/Captopril
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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