| Captopril reduces the VE/VCO2 ratio in myocardial infarction patients with low ejection fraction. | |
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MedLine Citation:
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PMID: 9824003 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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STUDY OBJECTIVES: To determine whether captopril (CAP) therapy had an effect on the minute ventilation/carbon dioxide output (VE/VCO2) ratio at submaximal levels of exercise in asymptomatic patients with reduced left ventricular function after myocardial infarction. DESIGN: Double blinded, randomized, prospective, repeated measures. PATIENTS AND INTERVENTIONS: One hundred thirty-five patients with left ventricular ejection fractions of < 40% were randomly assigned to a treatment group (CAP; n = 62) or a placebo group (PLC; n = 73). Subjects had cycle ergometer exercise tests at 2 to 6 months (T1), 10 to 14 months (T2), and > 22 months (T3) postmyocardial infarction. MEASUREMENTS: Oxygen uptake (VO2), VCO2, and VE were measured throughout each exercise test. Dependent variables were peak VO2 (VO2peak), the ventilatory anaerobic threshold (VAT), and the VE/VCO2 ratio measured at 30 W and at 75% VO2peak. RESULTS: VO2peak and VAT did not differ as a result of treatment (CAP vs PLC; p = 0.92 and 0.80) or over time (T1 vs T2 vs T3; p = 0.51 and 0.07). VE/VCO2 was significantly lower for CAP at 30 W (p = 0.05) and, although lower at 75% VO2peak, did not obtain statistical significance (p = 0.22). The between group differences were larger at T2 and T3 when compared with T1. CONCLUSIONS: CAP resulted in a reduced VE/VCO2 ratio during submaximal exercise. The reduced ventilation may permit patients to perform their normal activities of daily living at a lower perception of difficulty, reduce symptoms, and provide an improved quality of life. |
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Authors:
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T R McConnell; F J Menapace; L H Hartley; M A Pfeffer |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Chest Volume: 114 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 1998 Nov |
Date Detail:
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Created Date: 1998-12-09 Completed Date: 1998-12-09 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1289-94 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiology, Geisinger Medical Center, Danville, PA 17822-2160, USA. tmcconnell@psghs.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anaerobic Threshold Angiotensin-Converting Enzyme Inhibitors / pharmacology* Captopril / pharmacology* Carbon Dioxide / physiology* Double-Blind Method Exercise Test Female Humans Male Middle Aged Myocardial Infarction / physiopathology* Oxygen Consumption / drug effects Prospective Studies Pulmonary Gas Exchange / drug effects* Pulmonary Ventilation / drug effects* Stroke Volume* Ventricular Function, Left* |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 124-38-9/Carbon Dioxide; 62571-86-2/Captopril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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