Document Detail


Captopril modifies the hemodynamic and neuroendocrine responses to sodium nitroprusside in hypertensive patients.
MedLine Citation:
PMID:  3512428     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine if clinically effective doses of the antihypertensive agent captopril affected the neuronal release of norepinephrine or baroreflex sensitivity, changes in plasma norepinephrine concentration and heart rate were related to the changes in mean arterial pressure seen during the intravenous infusion of stepwise incremental doses of sodium nitroprusside before and during captopril treatment in eight hypertensive men with normal or low plasma renin activity. At all times, significant linear correlations were found between the decrease in mean arterial pressure and the dose of sodium nitroprusside, the increase in heart rate and the decrease in mean arterial pressure, and the increase in plasma norepinephrine concentration and the decrease in mean arterial pressure. When the subjects were treated with captopril (25 mg t.i.d.) for 2 to 4 weeks, supine mean arterial pressure decreased from 130 to 114 mm Hg (-12%; p less than 0.05), heart rate did not change, supine and upright plasma renin activity increased, while supine plasma norepinephrine and epinephrine concentration decreased slightly. Therapy with captopril (25 mg t.i.d.) increased baroreflex sensitivity, as assessed by the slope of the regression line relating the increase in heart rate to the decrease in mean arterial pressure, and increased the responsiveness of the sympathetic nervous system, as assessed by the slope of the regression line relating the increase in plasma norepinephrine concentration to the decrease in mean arterial pressure. These increases were accompanied by a decrease in the slope of the regression line relating the decrease in mean arterial pressure to the dose of sodium nitroprusside and thus were associated with a decreased sensitivity to the vasodepressor effects of sodium nitroprusside.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
W A Clementi; N L Durst; J L McNay; T K Keeton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension     Volume:  8     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-04-11     Completed Date:  1986-04-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  229-37     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Blood Pressure / drug effects
Captopril / pharmacology,  therapeutic use*
Ferricyanides / diagnostic use*
Heart Rate / drug effects
Humans
Hypertension / blood,  drug therapy*,  physiopathology
Male
Middle Aged
Nitroprusside / diagnostic use*
Norepinephrine / blood,  metabolism*
Pressoreceptors / drug effects*,  physiology
Renin / blood
Sympathetic Nervous System / drug effects*,  physiology
Chemical
Reg. No./Substance:
0/Ferricyanides; 15078-28-1/Nitroprusside; 51-41-2/Norepinephrine; 62571-86-2/Captopril; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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