| Captopril and the maintenance of blood pressure after sinoaortic denervation in the rabbit. | |
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MedLine Citation:
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PMID: 6269679 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. At a dose of 1 mg/kg intravenously, captopril lowered blood pressure in conscious rabbits, that had undergone denervation of sinoaortic baroreceptors, but had no effect on heart rate. In sham-operated controls, this dose caused only an increase in heart rate. 2. In the same experiments, captopril caused a substantial inhibition of plasma angiotensin converting enzyme (CE) activity of rapid onset and gradual decline over 2 to 3 h. The time course of recovery of blood pressure and plasma CE activity were similar. 3. Saralasin, by intravenous infusion, lowered blood pressure in sinoaortic rabbits but to a smaller extent than captopril. 4. The fall in blood pressure observed after captopril is not dependent on the integrity of baroreceptor afferents. |
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Authors:
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M A Petty; J L Reid |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of pharmacology Volume: 72 ISSN: 0007-1188 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 1981 Apr |
Date Detail:
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Created Date: 1981-12-15 Completed Date: 1981-12-15 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 645-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin-Converting Enzyme Inhibitors Animals Aorta, Thoracic / innervation* Blood Pressure / drug effects* Captopril / pharmacology* Carotid Sinus / innervation* Denervation Heart Rate / drug effects Male Pressoreceptors / physiology Proline / analogs & derivatives* Rabbits Saralasin / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 147-85-3/Proline; 34273-10-4/Saralasin; 62571-86-2/Captopril |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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