Document Detail

Captopril-induced hyponatremia with irreversible neurologic damage.
MedLine Citation:
PMID:  3907348     Owner:  NLM     Status:  MEDLINE    
A 61-year-old Chinese-American man with a history of congestive heart failure and hypertension was admitted to the San Francisco Veterans Administration Hospital with confusion, cortical blindness, and generalized flaccidity. Serum sodium level on admission was 114 meq/liter. Administration of captopril had been begun for afterload reduction two weeks before admission with a concomitant fall in serum sodium level from 137 meq/liter to 126 meq/liter in one week. A history of marked thirst with consumption of large volumes of water was reported for over one week prior to hospitalization. Despite correction of the hyponatremia within 24 hours at a rate of 0.9 meq/liter per hour, the patient remained semi-comatose and died four days later with a gastrointestinal bleed. It is suggested that the thirst phenomenon and hyponatremia were caused by the introduction of captopril. This lead to irreversible neurologic damage and death, despite the correction of the serum sodium level.
H I Al-Mufti; A I Arieff
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American journal of medicine     Volume:  79     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-01-14     Completed Date:  1986-01-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  769-71     Citation Subset:  AIM; IM    
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MeSH Terms
Captopril / adverse effects*,  therapeutic use
Heart Failure / drug therapy
Hyponatremia / chemically induced*,  complications
Middle Aged
Nervous System Diseases / etiology*
Sodium / blood
Thirst / drug effects
Reg. No./Substance:
62571-86-2/Captopril; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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