| Captopril-induced changes in large arteries in essential hypertension. | |
| | |
MedLine Citation:
|
PMID: 6328988 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effect on large arteries of the converting enzyme inhibitor captopril was studied in men with sustained essential hypertension with two different hemodynamic parameters: (1) systemic arterial compliance and (2) brachial artery diameter. After captopril administration, a 20 percent increase in arterial compliance was observed. The same increase was obtained with a 5 percent (acute experiment) and a 15 percent (short-term experiment) decrease in blood pressure, indicating that the decrease in pressure could not explain exclusively the increase in compliance. This assumption was studied with determinations of brachial artery diameter using original pulsed Doppler systems. After captopril administration, brachial artery diameter increased markedly despite the decrease in blood pressure. In addition to its effect on small arteries, the converting enzyme inhibitor captopril also has a special effect on the large arteries of patients with essential hypertension. |
| | |
Authors:
|
A C Simon; J A Levenson; J L Bouthier; M E Safar |
Related Documents
:
|
18031738 - Pharmacological profile of the new inotropic agent at-11. 10225478 - Antihypertensive drugs and the nervous system: ace-inhibitors restore oscillatory poten... 7943408 - Restraining effects of captopril on sympathetic excitatory responses in dogs: a spectra... 3034018 - Comparative double-blind study of ramipril and captopril in mild to moderate essential ... 2674288 - Study of different anaesthetic techniques on pulmonary haemodynamics during mitral comm... 6704008 - Effects of topical betaxolol in ocular hypertensive patients. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The American journal of medicine Volume: 76 ISSN: 0002-9343 ISO Abbreviation: Am. J. Med. Publication Date: 1984 May |
Date Detail:
|
Created Date: 1984-07-05 Completed Date: 1984-07-05 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0267200 Medline TA: Am J Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 71-5 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angiotensin-Converting Enzyme Inhibitors Arteries / drug effects* Blood Pressure / drug effects Brachial Artery / drug effects Captopril / pharmacology, therapeutic use* Cardiac Output / drug effects Heart Rate / drug effects Humans Hypertension / drug therapy*, physiopathology Male Proline / analogs & derivatives* Vascular Resistance / drug effects* |
| Chemical | |
Reg. No./Substance:
|
0/Angiotensin-Converting Enzyme Inhibitors; 147-85-3/Proline; 62571-86-2/Captopril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of captopril on hepatic venous pressure and blood flow in patients with liver cirrhosis.
Next Document: Effects of captopril on cerebral blood flow in normotensive and hypertensive rats.