Document Detail

Captopril-induced changes in large arteries in essential hypertension.
MedLine Citation:
PMID:  6328988     Owner:  NLM     Status:  MEDLINE    
The effect on large arteries of the converting enzyme inhibitor captopril was studied in men with sustained essential hypertension with two different hemodynamic parameters: (1) systemic arterial compliance and (2) brachial artery diameter. After captopril administration, a 20 percent increase in arterial compliance was observed. The same increase was obtained with a 5 percent (acute experiment) and a 15 percent (short-term experiment) decrease in blood pressure, indicating that the decrease in pressure could not explain exclusively the increase in compliance. This assumption was studied with determinations of brachial artery diameter using original pulsed Doppler systems. After captopril administration, brachial artery diameter increased markedly despite the decrease in blood pressure. In addition to its effect on small arteries, the converting enzyme inhibitor captopril also has a special effect on the large arteries of patients with essential hypertension.
A C Simon; J A Levenson; J L Bouthier; M E Safar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of medicine     Volume:  76     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1984 May 
Date Detail:
Created Date:  1984-07-05     Completed Date:  1984-07-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  71-5     Citation Subset:  AIM; IM    
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors
Arteries / drug effects*
Blood Pressure / drug effects
Brachial Artery / drug effects
Captopril / pharmacology,  therapeutic use*
Cardiac Output / drug effects
Heart Rate / drug effects
Hypertension / drug therapy*,  physiopathology
Proline / analogs & derivatives*
Vascular Resistance / drug effects*
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 147-85-3/Proline; 62571-86-2/Captopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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