| Captopril or conventional therapy in hypertensive type II diabetics. Three-year analysis. | |
| | |
MedLine Citation:
|
PMID: 8500859 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effects of long-term treatment with captopril and conventional therapy on albuminuria and metabolic parameters were compared in 74 hypertensive type II diabetics with normal serum creatinine. Patients were treated double-blind with either captopril monotherapy or combined with hydrochlorothiazide or therapy with metoprolol, hydrochlorothiazide, or both for 36 months. The treatment was titrated to achieve goal diastolic blood pressure of < or = 85 mm Hg. The reductions in blood pressures during treatment were similar in patients with (n = 21) and without (n = 53) microalbuminuria treated with either captopril or conventional therapy. No significant changes in albuminuria occurred in normoalbuminuric patients with either therapy. Although albuminuria fell in nearly all patients with microalbuminuria treated with captopril, it rose in eight of 12 patients on conventional therapy, with macroalbuminuria developing in two of them. Renal function was preserved by both types of treatment in both patient groups. Long-term treatment with either conventional therapy or captopril did not alter metabolic variables. We conclude that captopril alone or in combination decreases albuminuria and prevents the development of macroalbuminuria in hypertensive type II diabetics with persistent microalbuminuria. The renoprotective effect of this agent, however, remains to be demonstrated with longer term data on renal function. Aggressive antihypertensive treatment with either captopril or conventional therapy appears to be effective in preventing the onset of microalbuminuria in most normoalbuminuric patients. In contrast, with previous short-term studies, the use of converting enzyme inhibitors or conventional therapy did not cause adverse metabolic effects. |
| | |
Authors:
|
Y Lacourcière; A Nadeau; L Poirier; G Tancrède |
Related Documents
:
|
7159899 - The longer term efficacy of vasodilators in heart failure. 13678869 - Effects of candesartan in patients with chronic heart failure and reduced left-ventricu... 6102939 - An open comparison between free and a fixed combination of diuretic and beta-blocker in... 22503099 - Laser-assisted nasal decolonization of staphylococcus aureus, including methicillin-res... 19569069 - Metabolic syndrome increases mortality in heart failure. 2676169 - Hemodynamic and clinical effects of captopril in patients with severe congestive heart ... 22411569 - One thousand consecutive mini-gastric bypass: short- and long-term outcome. 10759039 - A randomized trial of two treatments for mild traumatic brain injury: 1 year follow-up. 20430189 - The relationship between inhalational anesthetic requirements and the severity of liver... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Hypertension Volume: 21 ISSN: 0194-911X ISO Abbreviation: Hypertension Publication Date: 1993 Jun |
Date Detail:
|
Created Date: 1993-07-01 Completed Date: 1993-07-01 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 7906255 Medline TA: Hypertension Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 786-94 Citation Subset: IM |
Affiliation:
|
Hypertension Research Unit, CHUL Research Center, Centre Hospitalier de l'Université Laval, Ste-Foy, Quebec, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Albuminuria / urine Blood Pressure / drug effects Captopril / therapeutic use* Diabetes Mellitus, Type 2 Diabetic Angiopathies / drug therapy*, metabolism, physiopathology Double-Blind Method Drug Therapy, Combination Female Humans Hydrochlorothiazide / therapeutic use Hypertension / drug therapy*, metabolism, physiopathology Kidney / physiopathology Male Metoprolol / therapeutic use Middle Aged Prospective Studies |
| Chemical | |
Reg. No./Substance:
|
37350-58-6/Metoprolol; 58-93-5/Hydrochlorothiazide; 62571-86-2/Captopril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Sucrose does not raise blood pressure in rats maintained on a low salt intake.
Next Document: Effect of diltiazem on glomerular heparan sulfate and albuminuria in diabetic rats.