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MedLine Citation:
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PMID: 8645078 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Captopril, a competitive inhibitor of angiotensin-converting enzyme, is widely used in the treatment of hypertension and heart failure. Captopril is known to be associated with dermatologic, hematologic, and pulmonary adverse effects. However, hepatotoxicity is extremely rare. A patient with severe cholestatic jaundice induced by captopril is presented. On admission to the hospital, the patient was diagnosed and treated as having cholangitis. Review of the literature showed similar occurrences in other patients. Patients treated with captopril who develop "atypical cholangitis" should be suspected of having captopril-associated liver damage. |
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Authors:
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A Nissan; R M Spira; D Seror; Z Ackerman |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Archives of surgery (Chicago, Ill. : 1960) Volume: 131 ISSN: 0004-0010 ISO Abbreviation: Arch Surg Publication Date: 1996 Jun |
Date Detail:
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Created Date: 1996-07-15 Completed Date: 1996-07-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9716528 Medline TA: Arch Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 670-1 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, Hadassah University Hospital Mount Scopus, Jerusalem, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Captopril / adverse effects* Cholangitis / chemically induced*, diagnosis Cholestasis / chemically induced* Diagnosis, Differential Female Humans Hypertension / drug therapy |
| Chemical | |
Reg. No./Substance:
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62571-86-2/Captopril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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