Document Detail

Captopril administered at night restores the diurnal blood pressure rhythm in adequately controlled, nondipping hypertensives.
MedLine Citation:
PMID:  16142596     Owner:  NLM     Status:  MEDLINE    
The aim of our study was to evaluate whether captopril administered at night, can shift the circadian blood pressure (BP) from a nondipper to a dipper pattern in adequately controlled hypertensive patients, who continued their antihypertensive therapy. In a prospective, randomized, double blind, placebo-controlled designed study, we enrolled 121 treated, adequately controlled nondipping hypertensive patients. All patients were randomly assigned to 12.5 mg captopril or placebo treatment administered at night. In case of nondippers, the dosage of captopril or placebo was doubled after two weeks of treatment, while for dippers antihypertensive regimens were not changed. After another two weeks, all patients underwent ambulatory BP monitoring. Our results show that at the end of the active treatment period, the prevalence of a dipping diurnal BP pattern in the captopril group (70%) was significantly higher than that in the placebo group (9.8%, P < 0.001). Nighttime BP, night/day BP ratio, nighttime BP load and 24-h systolic BP were significantly lower after 4 weeks nighttime captopril treatment compared to baseline. In conclusion, the present study demonstrates for the first time that captopril administered at night can restore the diurnal BP rhythm and decrease the elevated night/day BP ratio in appropriately controlled, nondipper hypertensive patients. These results were mainly due to the decrease of nighttime BP.
Yuan-Gang Qiu; Jian-Hua Zhu; Qian-Min Tao; Ping Zheng; Jun-Zhu Chen; Shen-Jiang Hu; Fu-Rong Zhang; Liang-Rong Zheng; Li-Li Zhao; Xue-Yan Yao
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy     Volume:  19     ISSN:  0920-3206     ISO Abbreviation:  Cardiovasc Drugs Ther     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-09-05     Completed Date:  2006-01-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8712220     Medline TA:  Cardiovasc Drugs Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  189-95     Citation Subset:  IM    
Department of Cardiology, the First Affiliated Hospital, Zhejiang University, College of Medicine, 79 Qingchun Road, Hangzhou 310003, People's Republic of China.
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MeSH Terms
Aged, 80 and over
Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
Blood Pressure / drug effects*
Captopril / therapeutic use*
Circadian Rhythm*
Double-Blind Method
Heart Rate / drug effects
Hypertension / drug therapy*,  physiopathology
Middle Aged
Prospective Studies
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 62571-86-2/Captopril
Comment In:
Cardiovasc Drugs Ther. 2005 May;19(3):169-71   [PMID:  16142592 ]

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