Document Detail

Capsule excision and Ologen implantation for revision after glaucoma drainage device surgery.
MedLine Citation:
PMID:  20405139     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: There is little information available about surgical management after failed glaucoma drainage device (GDD) surgery. We present the outcome of capsule excision after failed GDD surgery compared to capsule excision with additional use of a biodegradable implant (Ologen, version 2) as a placeholder. METHODS: In an observational comparative case series of 19 patients undergoing excision of the GDD capsule, ten prospectively observed consecutive patients were treated by excision of the capsule, topical mitomycin C application, and implantation of an 10 x 10 x 2 mm-sized Ologen implant (group A) while 9 retrospectively observed consecutive patients were treated by excision of the capsule and topical mitomycin C application alone (group B). RESULTS: Mean preoperative IOP was 29.4 mmHg for group A and 27.6 mmHg for group B, while mean postoperative IOP at the last follow-up (mean follow-up 11.2 (group A) and 8.6 (group B) months) was 17.3 mmHg for group A and 19.3 mmHg for group B (p > 0.05). Follow-up of the two groups demonstrated a significant difference in success rate (log-rank test, p = 0.04) in favor of group A. No further pressure-reducing surgery was necessary in any of the patients in group A, but it was needed in three of nine patients in group B. CONCLUSIONS: Although our study has the limitations of small sample size and observational study design, it shows that further investigation is warranted into the potential of Ologen in revision surgery after GDD implantation.
André Rosentreter; Anne C Mellein; Walter W Konen; Thomas S Dietlein
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2010-04-20
Journal Detail:
Title:  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie     Volume:  248     ISSN:  1435-702X     ISO Abbreviation:  Graefes Arch. Clin. Exp. Ophthalmol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-07-27     Completed Date:  2010-09-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8205248     Medline TA:  Graefes Arch Clin Exp Ophthalmol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1319-24     Citation Subset:  IM    
Department of Ophthalmology, University of Cologne, Joseph-Stelzmann-Strasse 9, Cologne, Germany.
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MeSH Terms
Absorbable Implants*
Blister / surgery*
Follow-Up Studies
Glaucoma / surgery*
Glaucoma Drainage Implants*
Intraocular Pressure / physiology
Microscopy, Acoustic
Middle Aged
Postoperative Complications
Prospective Studies
Prosthesis Failure*
Prosthesis Implantation*
Tonometry, Ocular
Reg. No./Substance:
0/Glycosaminoglycans; 0/atelocollagen; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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