Document Detail

Capsule endoscopy findings in patients with suspected Crohn's disease and biochemical markers of inflammation.
MedLine Citation:
PMID:  16569524     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Because it provides a direct view of superficial lesions in the small bowel, capsule endoscopy is a promising diagnostic tool for studying patients with suspected Crohn's disease undetected by conventional modalities. AIM: To assess the role of capsule endoscopy in the diagnosis of patients with suspected Crohn's disease. PATIENTS AND METHODS: Thirty-eight patients (16 males, mean age 46.2 years) with suspected Crohn's disease but negative at conventional imaging were examined using capsule endoscopy. They were divided into 2 groups: 12 patients with ongoing symptoms (Group 1), and 26 with ongoing symptoms and biochemical markers of inflammation (Group 2). Capsule endoscopy findings were classified as diagnostic (multiple erosions/ulcerations), suspicious (<or=3 erosions/ulcerations), non-specific and normal. RESULTS: Capsule endoscopy findings were diagnostic for Crohn's disease in 13 (34.2%) patients, suspicious in 2 (5.3%), non-specific in 4 (10.5%) and normal in 19 (50%), with an overall detection rate of 39.5%. The yield of positive findings was 8.3% in Group 1 and 46.2% in Group 2 (p=0.022). Capsule endoscopy findings prompted specific measures or patient management changes in 39.5% of patients. CONCLUSIONS: Capsule endoscopy has a high diagnostic yield in patients with suspected Crohn's disease and both clinical and biochemical markers of inflammation.
M De Bona; A Bellumat; E Cian; F Valiante; A Moschini; M De Boni
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2006-03-29
Journal Detail:
Title:  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver     Volume:  38     ISSN:  1590-8658     ISO Abbreviation:  Dig Liver Dis     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-01     Completed Date:  2006-11-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100958385     Medline TA:  Dig Liver Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  331-5     Citation Subset:  IM    
Gastroenterology Unit, S. Maria del Prato Hospital, Via Bagnols sur Ceze, 3, 32032 Feltre, Bl, Italy.
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MeSH Terms
Biological Markers / blood
Blood Sedimentation
C-Reactive Protein / metabolism
Crohn Disease / immunology*,  pathology*
Early Diagnosis
Endoscopy, Digestive System*
Intestine, Small / immunology,  pathology
Middle Aged
Reg. No./Substance:
0/Biological Markers; 0/Capsules; 9007-41-4/C-Reactive Protein

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