Document Detail

Capsule around silicone implants in diabetic rats: histological and biochemical study.
MedLine Citation:
PMID:  3273108     Owner:  NLM     Status:  MEDLINE    
Polydimethylsiloxane (silicone) implants were subcutaneously placed in the back of diabetic and normal rats. After three months the rats were killed and the fibrous capsule around the implants was histologically and biochemically examined. A significant quantitative difference (p less than 0.001) was found in the thickness of the capsules, which were two to three times thicker in the diabetic animals. The biochemistry showed an increase of neutral salt-soluble collagen in the diabetic group; electrophoresis revealed only type I collagen in the diabetic and type I and III in the normal rats. From this experimental trial it seems that diabetes mellitus is another factor in formation of a thick capsule around silicone implants.
I J Peled; M R Wexler; S Shoshan; S B Moshe; D Gazit; I Bab; S Ticher
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Annals of plastic surgery     Volume:  17     ISSN:  0148-7043     ISO Abbreviation:  Ann Plast Surg     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1990-04-16     Completed Date:  1990-04-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7805336     Medline TA:  Ann Plast Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  288-91     Citation Subset:  IM    
Department of Plastic and Maxillofacial Surgery, Hadassah University Hospital, Hebrew University, Faculty of Medicine and Dental Medicine, Jerusalem, Israel.
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MeSH Terms
Blood Glucose / analysis
Diabetes Mellitus, Experimental / metabolism,  pathology*
Dimethylpolysiloxanes / adverse effects
Disease Models, Animal
Glucose Tolerance Test
Prostheses and Implants / adverse effects*
Prosthesis Failure
Silicone Elastomers / adverse effects*
Skin / drug effects,  metabolism,  pathology
Reg. No./Substance:
0/Blood Glucose; 0/Dimethylpolysiloxanes; 0/Silicone Elastomers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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