| Capsule thickness correlates with vascular density and blood flow within foreign-body capsules surrounding surgically implanted subcutaneous devices. | |
| | |
MedLine Citation:
|
PMID: 20618226 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Medical devices implanted in subcutaneous tissue elicit wound-healing events that encapsulate the device. To investigate the foreign-body response to devices of clinically relevant size, we studied the relationship between capsule thickness, vascular density, and blood flow within the capsule. In nine canines, we implanted 40 subcutaneous devices (polysulfone n=14, titanium n=17, silicone-coated n=9). Devices and surrounding tissue structures were harvested at 208 ± 142 (mean ± standard deviation) days after implantation. Tissues were processed for histological analysis with light microscopy. Foreign-body capsule (FBC) thickness and vascular density were determined. A subset of five animals was instrumented via thoracotomy for microsphere injections and reference blood sampling. In these animals, regional blood flow was determined in mL/min/g of tissue in the FBC to examine the relationship between capsule thickness and blood flow. One-way analysis of variance and linear regression analyses were performed. The FBC thickness was 0.92 ± 0.67 mm for all devices studied and was not influenced by device material. Capsule thickness correlated with vascular density for all devices (R(2)=0.85, P<0.0001) and for each device material (polysulfone R(2)=0.85, P<0.0001; silicone R(2)=0.95, P<0.0001; titanium R(2)=0.87, P<0.0001). Capsule thickness correlated modestly with blood flow for all devices studied (R(2)=0.59, P<0.0001) and for each device material (polysulfone R(2)=0.77, P<0.001; silicone R(2)=0.65, P=0.10; titanium R(2)=0.52, P=0.03). Capsule thickness, vascular density, and blood flow were similar within individual animals but variable across animals. Material type did not influence the thickness of FBCs surrounding devices of clinically relevant size. Capsule thickness correlated strongly with vascular density and modestly with blood flow within the capsule. Individual animals exhibited variable foreign-body responses. |
| | |
Authors:
|
Carlo R Bartoli; Menaka M Nadar; John J Godleski |
Related Documents
:
|
19821816 - Use of zirconia ceramic in the dexaide right ventricular assist device journal bearing. 18969716 - Multi-pumping flow systems: an automation tool. 6461796 - A simply constructed system for mean blood flow measurement. 19479606 - High risk infusions--accuracy compromised by changes in patient venous pressure. 1575286 - Grading of hepatic schistosomiasis by the use of ultrasonography. 10516416 - Doppler velocity and flow through the aortic isthmus in normal term neonates. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: Artificial organs Volume: 34 ISSN: 1525-1594 ISO Abbreviation: Artif Organs Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-10-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7802778 Medline TA: Artif Organs Country: United States |
Other Details:
|
Languages: eng Pagination: 857-61 Citation Subset: IM |
Copyright Information:
|
© 2010, Copyright the Authors. Artificial Organs © 2010, International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc. |
Affiliation:
|
University of Louisville School of Medicine, MD/PhD Program, Louisville, KY, USA. crbart02@louisville.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
| Grant Support | |
ID/Acronym/Agency:
|
R01 ES00002/ES/NIEHS NIH HHS; R01 ES12972/ES/NIEHS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Technical standards of a foldable capsular vitreous body in terms of mechanical, optical, and biocom...
Next Document: Conversion to sirolimus in renal transplant recipients: a single-center experience.