Document Detail


Capsaicin-sensitive nerves exert an inhibitory effect on the development of fibrin-induced pulmonary edema in rats.
MedLine Citation:
PMID:  2476955     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was undertaken to evaluate the role of vagal nerves in the development of neurogenic pulmonary edema. We injected fibrinogen and thrombin into the cisterna magna of rats, a model of neurogenic pulmonary edema. When the vagal nerves were left intact, pulmonary edema occurred (fibrin-induced pulmonary edema) at a rate of 33%. Vagotomy at the midcervical portion increased the incidence of pulmonary edema to a rate of 100%, whereas pretreatment with atropine did not affect the incidence. These results suggested that vagal afferent nerves or nonadrenergic-noncholinergic efferent nerves played an important role in inhibiting the development of fibrin-induced pulmonary edema. Furthermore, in vagotomized and vagal nerve-intact rats pretreated with capsaicin, the incidence of pulmonary edema was 100%. Pretreatment with a substance P antagonist, [D-Pro2, D-Trp7,9]-SP, also increased the incidence to 100% in the vagal nerve-intact rats. On the other hand, intravenous administration of some neuropeptides that may be released from the capsaicin-sensitive nerves (e.g., substance P or calcitonin gene-related peptide) inhibited the development of pulmonary edema in vagotomized rats. We concluded that the vagal capsaicin-sensitive nerves exerted an inhibitory effect on the development of fibrin-induced pulmonary edema.
Authors:
Y Hashiba; N Ishikawa; T Sumita; K Takagi; H Hidaka; T Satake
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  140     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1989-10-19     Completed Date:  1989-10-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  652-8     Citation Subset:  AIM; IM    
Affiliation:
Second Department of Internal Medicine, Nagoya University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Calcitonin Gene-Related Peptide
Capsaicin / pharmacology*
Extracellular Space / metabolism
Fibrin*
Heart Rate / drug effects
Lung / metabolism
Male
Neuropeptides / pharmacology
Pulmonary Edema / chemically induced,  metabolism,  physiopathology*
Rats
Rats, Inbred Strains
Substance P / analogs & derivatives,  antagonists & inhibitors,  pharmacology
Vagotomy
Vagus Nerve / drug effects,  physiopathology*
Chemical
Reg. No./Substance:
0/Neuropeptides; 33507-63-0/Substance P; 404-86-4/Capsaicin; 80434-86-2/substance P, prolyl(2)-tryptophan(7,9)-; 83652-28-2/Calcitonin Gene-Related Peptide; 9001-31-4/Fibrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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