Document Detail


Capsaicin pretreatment inhibits vagal cholinergic and non-cholinergic control of pulmonary mechanics in the guinea pig.
MedLine Citation:
PMID:  6728043     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of vagal nerve stimulation, ether, capsaicin, histamine and substance P (SP) on lung resistance (RL) and dynamic lung compliance (CDYN) were studied in anaesthetized guinea pigs. The in vivo responses in control animals were compared with the effects after systemic pretreatment with capsaicin or local application of capsaicin on the cervical vagal nerves. Vagal nerve stimulation induced an increase in RL and a fall in CDYN. Significant changes in RL and CDYN (more than 50%) were still present after atropine, while the vagal heart response was abolished. Systemic or local capsaicin pretreatment abolished the atropine-resistant vagal effect on RL and CDYN. The atropine-sensitive changes in pulmonary mechanics upon vagal stimulation were significantly reduced by capsaicin pretreatment. The increase in RL and a fall in CDYN induced by ether and capsaicin was significantly reduced or abolished by systemic capsaicin pretreatment, while the histamine-induced bronchoconstriction was only slightly reduced. Ether and capsaicin seemed also to activate capsaicin-sensitive neurons of non-vagal origin since they still caused large effects in animals, which had been locally pretreated with capsaicin on the vagal nerves. The increased RL and decreased CDYN induced by SP was unchanged in capsaicin-pretreated animals. The tracheal tension increase in vitro induced by acetylcholine and histamine was uninfluenced by systemic capsaicin pretreatment. The atropine-sensitive tracheal contraction and atropine-resistant relaxation upon field stimulation seemed also to be unchanged after capsaicin pretreatment.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
C R Martling; A Saria; P Andersson; J M Lundberg
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Naunyn-Schmiedeberg's archives of pharmacology     Volume:  325     ISSN:  0028-1298     ISO Abbreviation:  Naunyn Schmiedebergs Arch. Pharmacol.     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-07-18     Completed Date:  1984-07-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0326264     Medline TA:  Naunyn Schmiedebergs Arch Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  343-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / pharmacology
Animals
Atropine / pharmacology*
Bronchi / physiology
Capsaicin / pharmacology*
Choline O-Acetyltransferase / metabolism
Electric Stimulation
Female
Guinea Pigs
Histamine / pharmacology
Lung Compliance / drug effects*
Male
Muscle Contraction / drug effects
Muscle, Smooth / physiology*
Receptors, Muscarinic / physiology
Respiratory Function Tests
Trachea / physiology
Vagus Nerve / drug effects,  physiology*
Chemical
Reg. No./Substance:
0/Receptors, Muscarinic; 404-86-4/Capsaicin; 51-45-6/Histamine; 51-55-8/Atropine; 51-84-3/Acetylcholine; EC 2.3.1.6/Choline O-Acetyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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