| Capsaicin induces de-differentiation of activated hepatic stellate cell. | |
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MedLine Citation:
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PMID: 22905849 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Hepatic stellate cells (HSC) play a key role in liver fibrogenesis. Activation of PPARγ and inhibition of fibrogenic molecules are potential strategies to block HSC activation and differentiation. A number of natural products have been suggested to have antifibrotic effects for the de-activation and de-differentiation of HSCs. The purpose of this study was to investigate the in vitro effects of capsaicin on HSC de-activation and de-differentiation. The results demonstrated that capsaicin induced quiescent phenotype in GRX via PPARγ activation. Significant decrease in COX-2 and type I collagen mRNA expression was observed in the first 24 h of treatment. These events preceded the reduction of TGF-β1 and total collagen secretion. Thus, capsaicin promoted down-regulation of HSC activation by its antifibrotic and anti-inflammatory actions. These findings demonstrate that capsaicin may have potential as a novel therapeutic agent for the treatment of liver fibrosis. |
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Authors:
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Shanna Bitencourt; Fernanda C de Mesquita; Eduardo Caberlon; Gabriela V da Silva; Bruno S Basso; Gabriela A Ferreira; Jarbas R de Oliveira |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-21 |
Journal Detail:
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Title: Biochemistry and cell biology = Biochimie et biologie cellulaire Volume: - ISSN: 1208-6002 ISO Abbreviation: Biochem. Cell Biol. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8606068 Medline TA: Biochem Cell Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Laboratório de Pesquisa em Biofísica Celular e Inflamação, Pontifícia Universidade Católica do Rio Grande do Sul, PUCRS, Avenida Ipiranga 6681, prédio 12, bloco C, sala 221, CEP 90619-900, Porto Alegre, Rio Grande do Sul, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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