Document Detail


Capsaicin induces de-differentiation of activated hepatic stellate cell.
MedLine Citation:
PMID:  22905849     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Hepatic stellate cells (HSC) play a key role in liver fibrogenesis. Activation of PPARγ and inhibition of fibrogenic molecules are potential strategies to block HSC activation and differentiation. A number of natural products have been suggested to have antifibrotic effects for the de-activation and de-differentiation of HSCs. The purpose of this study was to investigate the in vitro effects of capsaicin on HSC de-activation and de-differentiation. The results demonstrated that capsaicin induced quiescent phenotype in GRX via PPARγ activation. Significant decrease in COX-2 and type I collagen mRNA expression was observed in the first 24 h of treatment. These events preceded the reduction of TGF-β1 and total collagen secretion. Thus, capsaicin promoted down-regulation of HSC activation by its antifibrotic and anti-inflammatory actions. These findings demonstrate that capsaicin may have potential as a novel therapeutic agent for the treatment of liver fibrosis.
Authors:
Shanna Bitencourt; Fernanda C de Mesquita; Eduardo Caberlon; Gabriela V da Silva; Bruno S Basso; Gabriela A Ferreira; Jarbas R de Oliveira
Related Documents :
11248559 - Transcriptional regulation in lymphocytes.
20543829 - Role for the mov10 rna helicase in polycomb-mediated repression of the ink4a tumor supp...
12604819 - Kaposi's sarcoma-associated herpesvirus k8 protein interacts with hsnf5.
14999129 - Regulation of transcriptional coactivator pgc-1alpha.
22500729 - Sex differences in transcriptional expression of fabps in zebrafish liver after chronic...
10076769 - Cytochemistry of the functional domains of the nucleus in normal and in pathologic cond...
9382709 - Extracellular-matrix gene expression during mouse submandibular gland development.
8628299 - Interactions among sr proteins, an exonic splicing enhancer, and a lentivirus rev prote...
17827669 - Detection of neurotrophic factors in taste buds by laser capture microdissection, immun...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-21
Journal Detail:
Title:  Biochemistry and cell biology = Biochimie et biologie cellulaire     Volume:  -     ISSN:  1208-6002     ISO Abbreviation:  Biochem. Cell Biol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8606068     Medline TA:  Biochem Cell Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Laboratório de Pesquisa em Biofísica Celular e Inflamação, Pontifícia Universidade Católica do Rio Grande do Sul, PUCRS, Avenida Ipiranga 6681, prédio 12, bloco C, sala 221, CEP 90619-900, Porto Alegre, Rio Grande do Sul, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The use of synthetic mesh and the management of mesh extrusion in vaginal surgery.
Next Document:  Who Can Recognize Unfamiliar Faces? Individual Differences and Observer Consistency in Person Identi...