Document Detail

Capsaicin-induced neurogenic inflammation in the skin in patients with symptoms induced by odorous chemicals.
MedLine Citation:
PMID:  20923466     Owner:  NLM     Status:  In-Process    
BACKGROUND: Intradermal injection of capsaicin induces the axonal release of neuropeptides, vasodilatation and flare, e.g. neurogenic inflammation. The spatial profile of neurogenic inflammation in the skin has been studied in various experimental models. Polarization spectroscopy imaging introduced recently may be used for the quantitative assessment of the temporal profile of neurogenic inflammation expressed as erythema intensity.
PURPOSE: In the present study, we aimed to compare capsaicin-induced erythema intensity with the flare area in patients with symptoms induced by odorous chemicals, thereby comparing the temporal and spatial profiles of neurogenic inflammation.
METHODS: Sixteen patients fulfilling Cullen's criteria for multiple chemical sensitivity (MCS) and 15 eczema (EC) patients with airway symptoms elicited by odorous chemicals were compared with 29 age-matched, healthy controls. Participants were administered two intradermal injections of capsaicin 3.3 and 33μM. Erythema intensity was measured by polarization spectroscopy imaging and flare response was quantified by visual inspection.
RESULTS: Erythema intensity and flare area did not differ between patients and controls, and they were not correlated. Erythema intensity and flare area showed a dose-dependent increase (P<0.05). Erythema intensity increased with age at 3.3μM but not at 33μM capsaicin, whereas the flare area increased with age at both concentrations (P<0.05).
CONCLUSION: Capsaicin-induced erythema intensity and visual flare were normal in patients with MCS and EC patients with airway symptoms from odorous chemicals. Polarized light spectroscopy was a useful method for the measurement of the rapid temporal changes in erythema of experimental reactions.
Helle Holst; Lars Arendt-Nielsen; Holger Mosbech; Jørgen Serup; Jesper Elberling
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)     Volume:  17     ISSN:  1600-0846     ISO Abbreviation:  Skin Res Technol     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9504453     Medline TA:  Skin Res Technol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  82-90     Citation Subset:  IM    
Copyright Information:
© 2010 John Wiley & Sons A/S.
Dermatology Department, The Danish Research Centre for Chemical Sensitivities, Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
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