Document Detail

Capsaicin consumption, Helicobacter pylori CagA status and IL1B-31C>T genotypes: a host and environment interaction in gastric cancer.
MedLine Citation:
PMID:  22414649     Owner:  NLM     Status:  MEDLINE    
Gastric cancer (GC) has been associated with a complex combination of genetic and environmental factors. In contrast to most countries, available information on GC mortality trends showed a gradual increase in Mexico. Our aim was to explore potential interactions among dietary (chili pepper consumption), infectious (Helicobacter pylori) and genetic factors (IL1B-31 genotypes) on GC risk. The study was performed in three areas of Mexico, with different GC mortality rates. We included 158 GC patients and 317 clinical controls. Consumption of capsaicin (Cap), the pungent active substance of chili peppers, was estimated by food frequency questionnaire. H. pylori CagA status was assessed by ELISA, and IL1B-31 genotypes were determined by TaqMan assays and Pyrosequencing in DNA samples. Multivariate unconditional logistic regression was used to estimate potential interactions. Moderate to high Cap consumption synergistically increased GC risk in genetically susceptible individuals (IL1B-31C allele carriers) infected with the more virulent H. pylori (CagA+) strains. The combined presence of these factors might explain the absence of a decreasing trend for GC in Mexico. However, further research on gene-environment interactions is required to fully understand the factors determining GC patterns in susceptible populations, with the aim of recommending preventive measures for high risk individuals.
Lizbeth López-Carrillo; M Constanza Camargo; Barbara G Schneider; Liviu A Sicinschi; Raúl U Hernández-Ramírez; Pelayo Correa; Mariano E Cebrian
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-03-04
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  50     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-28     Completed Date:  2012-10-09     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  2118-22     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
National Institute of Public Health, Universidad 655, Santa María Ahuacatitlán, CP 62100, Cuernavaca, Morelos, Mexico.
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MeSH Terms
Adenocarcinoma / genetics*,  microbiology*
Antibodies, Bacterial / analysis
Capsaicin / adverse effects*
DNA / biosynthesis,  genetics
Gene-Environment Interaction
Helicobacter Infections / complications,  microbiology*
Helicobacter pylori / drug effects*,  immunology
Immunoglobulin G / analysis
Interleukin-1beta / genetics*
Logistic Models
Middle Aged
Polymerase Chain Reaction
Stomach Neoplasms / genetics*,  microbiology*
Grant Support
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Immunoglobulin G; 0/Interleukin-1beta; 404-86-4/Capsaicin; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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