Document Detail

Capsaicin-activated bronchial- and alveolar-initiated pathways regulating tracheal ciliary beat frequency.
MedLine Citation:
PMID:  7836127     Owner:  NLM     Status:  MEDLINE    
We questioned whether the prolonged stimulation of ciliary beat frequency (CBF) to a short exposure of low-dose capsaicin (Wong et al. J. Appl. Physiol. 68: 257-2580, 1990) could be due to the activation of indirect pathways involving neural reflexes initiated independently in the bronchi and alveoli. Tracheal CBF (CBFtr) was measured temporally in anesthetized groups of 10 dogs by means of heterodyne-mode correlation analysis laser light scattering. To elucidate the site of the afferent neural stimulation and the efferent mediators affecting the ciliated epithelium, capsaicin (3 nM) aerosol was delivered for 4 min, either predominantly to the bronchi or to the alveolar regions, with use of pulsed aerosol techniques. This resulted in 13 pg of bronchial (85%) and 10 pg of alveolar (96%) capsaicin deposited, which caused marked stimulation of CBFtr with maxima at 7 and 35 min, respectively. Prior administration of aerosolized indomethacin to the bronchi or aerosolized cromolyn to the alveoli inhibited the bronchial and alveolar responses, respectively. Prior administration of aerosolized hexamethonium to the tracheal lumen blocked the stimulatory CBFtr responses from both capsaicin challenges. Ipratropium or propranolol aerosols delivered to the tracheal lumen also inhibited these responses. It is proposed that these pathways comprise one set of sensitive mechanisms to ensure a prolonged stimulation of CBF to effect the removal of secretions and the irritant from the lungs.
M Eljamal; L B Wong; D B Yeates
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  77     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1995-02-28     Completed Date:  1995-02-28     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1239-45     Citation Subset:  IM    
Department of Medicine, University of Illinois at Chicago 60612.
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MeSH Terms
Bronchi / drug effects,  innervation,  physiology*
Capsaicin / administration & dosage,  pharmacology*
Cilia / drug effects
Cromolyn Sodium / pharmacology
Hexamethonium / pharmacology
Indomethacin / pharmacology
Ipratropium / pharmacology
Neural Pathways / drug effects,  physiology
Propranolol / pharmacology
Pulmonary Alveoli / drug effects,  innervation,  physiology*
Scattering, Radiation
Grant Support
Reg. No./Substance:
0/Aerosols; 15826-37-6/Cromolyn Sodium; 404-86-4/Capsaicin; 525-66-6/Propranolol; 53-86-1/Indomethacin; 60-26-4/Hexamethonium; 60205-81-4/Ipratropium

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